RESUMO
OBJECTIVE: To study the structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity. METHODS: By the assay systems of DPPH*, the antioxidant activity of six phenylethanoid glycosides from plants of Cistanche salsa was determined to investigate the relationship between the antioxidant activities and phenylethanoid glycosides's structural characteristics. RESULTS: The antioxidative activity of phenylethanoid glycosides was variant with dose-dependent effect. The sequence of the strength of the antioxidative activity of the six components was shown to be 2'-Acetylacteoside > Acteoside > or = Tubuloside B > or = Isoacteoside > Echinacoside > Cistanoside A. CONCLUSION: The antioxidative activity of phenylethanoid glycosides is related to the number of phenolic hydroxyl, steric hindrance, 2-acetyl on the middle glucopyranose, and the location of phenolic hydroxyl. Additionally, it may be related to the alpha, beta-unsaturated ketone of phenl-2-propenoyl.
Assuntos
Antioxidantes/química , Antioxidantes/farmacologia , Cistanche/química , Glicosídeos/química , Plantas Medicinais/química , Antioxidantes/isolamento & purificação , Sequestradores de Radicais Livres , Glucosídeos/química , Glucosídeos/farmacologia , Glicosídeos/farmacologia , Radical Hidroxila/metabolismo , Estrutura Molecular , Relação Estrutura-AtividadeRESUMO
OBJECTIVE: To study the chemical constituents of cultivated Cistanche salsa. METHODS: Compounds were isolated and purified on several chromatography, and then were identified by physico-chemical properties and structurally elucidated by spectral analysis. RESULTS: Seven compounds were isolated and identified as beta-sitosterol (I), daucosterol (II), beta-sitosteryl glucoside 3'-O-heptadecoicate (III), 8-hydroxygeraniol 1-beta-D-glucopyranoside (IV), 2-methanol-5-hydroxy-pyridine (V), betaine (VI), galactitol (VII). CONCLUSION: The chemical constituents of artificial cultivated Cistanche salsa are studied for the first time. Among them, compound III and IV are isolated from the plant for the first time, compound V is isolated from this genus for the first time.
Assuntos
Cistanche/química , Glucosídeos/isolamento & purificação , Plantas Medicinais/química , Piridoxina/análogos & derivados , Betaína/química , Betaína/isolamento & purificação , Cistanche/crescimento & desenvolvimento , Glucosídeos/química , Plantas Medicinais/crescimento & desenvolvimento , Piridoxina/química , Piridoxina/isolamento & purificação , Sitosteroides/química , Sitosteroides/isolamento & purificaçãoRESUMO
OBJECTIVE: To study the chemical constituents of Hedysarum polybotrys. METHOD: Chromatographic methods were used to isolate compounds from H. polybotrys and chemical and spectral methods were used to elucidate the structures of the isolated compounds. RESULT: Five compounds, N,N,N-trimethyl-tropaphone inner salt (hypaphorine) (1), octadecyl-3-methoxy-4-hydroxy-benzeneacrylate (2), 5,7,4'-trihydroxy-dihydroflavanone 5,7-di-O-beta-D-glucopyranoside (3), 3,4,5-trimethoxy cinnamic acid methy ester (4) and vanillic acid (5), were isolated from the roots of H. polybotrys. CONCLUSION: Compounds 1, 2 and 3 were obtained from this plant for the first time, while compounds 1 and 2 were isolated from Hedysarum for the first time.
Assuntos
Acrilatos/isolamento & purificação , Fabaceae/química , Indóis/isolamento & purificação , Plantas Medicinais/química , Acrilatos/química , Indóis/química , Conformação Molecular , Estrutura Molecular , Raízes de Plantas/químicaRESUMO
AIM: To study the chemical constituents of Hedysarum polybotrys Hand.-Mazz.. METHODS: The compounds were separated with Sephadex LH-20 and silica gel column chromatography, and their structures were identified on the basis of spectral analysis. RESULTS: Five compounds were identified as hedysalignan A (1), isoliquiritigenin (2), formononetin (3), calycosin (4) and ononin (5). CONCLUSION: Hedysalignan (1) is a new compound and the others were obtained from the plant for the first time.
Assuntos
Chalcona/análogos & derivados , Medicamentos de Ervas Chinesas/isolamento & purificação , Fabaceae/química , Furanos/isolamento & purificação , Glucosídeos/isolamento & purificação , Chalcona/química , Chalcona/isolamento & purificação , Chalconas , Medicamentos de Ervas Chinesas/química , Furanos/química , Glucosídeos/química , Isoflavonas/química , Isoflavonas/isolamento & purificação , Conformação Molecular , Estrutura Molecular , Raízes de Plantas/química , Plantas Medicinais/químicaRESUMO
OBJECTIVE: To investigate the chemical constituents from the root and rhizome of Rheum rhizastachyum. METHOD: The compounds were isolated by column chromatography on silica gel, Sephadex LH-20, MCI-gel CHP-20P separately and their structures were elucidated by chemical and spectral technology. RESULT: Six compounds were isolated and identified as chrysophanol, emodin, gallic acid, sucrose, 1-O-beta-D-glucopyranosyl-chrysophanols, 1-O-beta-D-glucopyranosyl-emodin. CONCLUSION: All the compounds were obtained from this plant for the first time.
Assuntos
Antraquinonas/isolamento & purificação , Emodina/isolamento & purificação , Plantas Medicinais/química , Rheum/química , Antraquinonas/química , Emodina/química , Ácido Gálico/química , Ácido Gálico/isolamento & purificação , Raízes de Plantas/química , Rizoma/químicaRESUMO
OBJECTIVE: To summarize the pharmacological function of oleanolic acid. METHOD: Based on the documents and related achievements, the pharmacological function and its mechanism including its clinical use were summed up. RESULT AND CONCLUSION: Oleanolic Acid is a natural chemical which has wide-ranging function and abundant source. But we should place the emphasis on improving its biotic utilization and effect on clinical treatment.
Assuntos
Hepatite Viral Humana/tratamento farmacológico , Ácido Oleanólico/farmacologia , Fitoterapia , Plantas Medicinais/química , Adjuvantes Imunológicos/farmacologia , Animais , Antineoplásicos Fitogênicos/farmacologia , Antivirais/farmacologia , Humanos , Hipoglicemiantes/farmacologia , Ácido Oleanólico/isolamento & purificaçãoRESUMO
OBJECTIVE: To study the chemical constituents in the root of Hedysarum polybotrys Hand.-Mazz.. METHOD: The constituents were isolated by Sephadex LH-20 and silica gel column chromatography, and their structures were identified on the basis of spectral analysis. RESULT: Five compounds, medicarpin (I), 3-hydroxy-9-methoxycoumestan (II), 3, 9-dihydroxycoumestan (III), beta-sitosterol (IV), beta-sitosterol-3-O-beta-D-glucoside (V) were obtained. CONCLUSION: Compounds II, III, V were obtained from the plant for the first time.
