Boarding pyroptosis onto nanotechnology for cancer therapy.

Pyroptosis, a non-apoptotic programmed cellular inflammatory death mechanism characterized by gasdermin (GSDM) family proteins, has gathered significant attention in the cancer treatment. However, the alarming clinical trial data indicates that pyroptosis-mediated cancer therapeutic efficiency is still unsatisfactory. It is essential to integrate the burgeoning biomedical findings and innovations with potent technology to hasten the development of pyroptosis-based antitumor drugs. Considering the rapid development of pyroptosis-driven cancer nanotherapeutics, here we aim to summarize the recent advances in this field at the intersection of pyroptosis and nanotechnology. First, the foundation of pyroptosis-based nanomedicines (NMs) is outlined to illustrate the reliability and effectiveness for the treatment of tumor. Next, the emerging nanotherapeutics designed to induce pyroptosis are overviewed. Moreover, the cross-talk between pyroptosis and other cell death modalities are discussed, aiming to explore the mechanistic level relationships to provide guidance strategies for the combination of different types of antitumor drugs. Last but not least, the opportunities and challenges of employing pyroptosis-based NMs in potential clinical cancer therapy are highlighted.

52 Gbps PAM4 receiver sensitivity study for 400GBase-LR8 system using directly modulated laser.

Real-time 52 Gbps PAM4 transmission is demonstrated over single mode fiber (SMF) using a directly modulated laser (DML) and a PHY chip. The inner eye optical modulation amplitude (OMA) receiver sensitivities were measured and compared using avalanche photodetector (APD) and PIN photodetector (PD) for the maximum and minimum chromatic dispersions (CDs) of 400GBase-LR8 link. The measured inner eye OMAs were -17.8 dBm and -18.8 dBm for + 10 ps/nm and -58 ps/nm of CDs at the KP4 bit error rate (BER) threshold of 2 × 10-4 using a PIN PD, respectively. The measured inner eye OMA was improved to -21.0 dBm for -58 ps/nm of CD at the KP4 BER threshold using an APD. Negligible OMA penalty (< 0.4 dB) was captured for operating DML at different bias currents of 40 mA and 60 mA using a PIN PD and an APD for both positive and negative CDs at the KP4 BER threshold.