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Expert Opin Drug Deliv ; 14(2): 179-187, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27397695

RESUMO

INTRODUCTION: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques are available to estimate the extent of oral drug absorption in humans. However, variations in certain physiological and physico-chemical factors are often not reflected in the results and the complex dynamic interplay between these factors is sometimes oversimplified with in vitro models. Areas covered: In vitro models to evaluate drug pharmacokinetics are briefly outlined, while both physiological and physico-chemical factors that may have an influence on these techniques are critically reviewed. The shortcomings identified for some of the in vitro techniques are discussed in conjunction with novel ways to improve and thereby overcome some challenges. Expert opinion: Although conventional in vitro methods and theories are used as basic guidelines to predict drug absorption, critical evaluations have identified some shortcomings. Advancements in technology have made it possible to investigate and understand the role of physiological and physico-chemical factors in drug delivery more clearly, which can be used to improve and refine the techniques to more closely mimic the in vivo environment.


Assuntos
Sistemas de Liberação de Medicamentos , Mucosa Intestinal/metabolismo , Preparações Farmacêuticas/administração & dosagem , Administração Oral , Descoberta de Drogas , Humanos , Absorção Intestinal , Modelos Biológicos , Preparações Farmacêuticas/química , Farmacocinética
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