Semantic Segmentation of Remote Sensing Data Based on Channel Attention and Feature Information Entropy.

The common channel attention mechanism maps feature statistics to feature weights. However, the effectiveness of this mechanism may not be assured in remotely sensing images due to statistical differences across multiple bands. This paper proposes a novel channel attention mechanism based on feature information called the feature information entropy attention mechanism (FEM). The FEM constructs a relationship between features based on feature information entropy and then maps this relationship to their importance. The Vaihingen dataset and OpenEarthMap dataset are selected for experiments. The proposed method was compared with the squeeze-and-excitation mechanism (SEM), the convolutional block attention mechanism (CBAM), and the frequency channel attention mechanism (FCA). Compared with these three channel attention mechanisms, the mIoU of the FEM in the Vaihingen dataset is improved by 0.90%, 1.10%, and 0.40%, and in the OpenEarthMap dataset, it is improved by 2.30%, 2.20%, and 2.10%, respectively. The proposed channel attention mechanism in this paper shows better performance in remote sensing land use classification.

Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress.

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in redox homeostasis, which protects cells from stress conditions such as reactive oxygen species and therefore exerts beneficial effects on suppression of carcinogenesis. In addition to their pivotal role in cellular physiology, accumulating innovative studies indicated that NRF2/KEAP1-governed pathways may conversely be oncogenic and cause therapy resistance, which was profoundly modulated by epigenetic mechanism. Therefore, targeting epigenetic regulation in NRF2/KEAP1 signaling is a potential strategy for cancer treatment. In this paper, the current knowledge on the role of NRF2/KEAP1 signaling in cancer oxidative stress is presented, with a focus on how epigenetic modifications might influence cancer initiation and progression. Furthermore, the prospect that epigenetic changes may be used as therapeutic targets for tumor treatment is also investigated.