RESUMO
Casearia sylvestris (Flacourtiaceae) is a plant which grows in the wild. The crude extract and pure substances from this plant induced partial inhibition of the PLA: (phospholipase A2) activity of snake venoms and some purified toxins. C. sylvestris extract efficiently neutralized the hemorrhagic and myotoxic activities caused by crude venoms and toxins.
Assuntos
Casearia/química , Inibidores Enzimáticos/farmacologia , Fosfolipases A/antagonistas & inibidores , Animais , Brasil , Cromatografia Gasosa , Cromatografia Líquida de Alta Pressão , Hemorragia/induzido quimicamente , Hemorragia/prevenção & controle , Doenças Musculares/induzido quimicamente , Doenças Musculares/prevenção & controle , Fosfolipases A2 , Extratos Vegetais/farmacologia , Venenos de Serpentes/antagonistas & inibidores , Venenos de Serpentes/enzimologia , Venenos de Serpentes/toxicidadeRESUMO
Macfadyena unguis-cati (L.) has been widely used in folk medicine as an anti-inflammatory, antimalarial and antivenereal. The purpose of this study was to chemically characterize the main plant components, and to evaluate the biological properties of some of the fractions derived from leaves (MACb) and liana (MACa) of this plant. Chemical characterization allowed the identification of the compounds corymboside, vicenin-2, quercitrin, chlorogenic acid, isochlorogenic acid, lupeol, beta-sitosterol, beta-sitosterylglucoside, allantoin and lapachol. The biological screening of fractions and/or purified substances derived from fractions revealed antitumoral and antitrypanosomal activities in fractions MACa/lapachol and MACb/MACb21, respectively. The anti-lipoxygenase and anti-cyclooxygenase effect seen in fractions MACa and MACb showed a partial correlation with the anti-inflammatory property attributed to this plant.
