RESUMO
This paper presents a study of 100 cases of leprosy of different clinical types. These 100 cases included 26 TT, 3 BT, 7 BB, 2 BL and 62 LL. All were subjected to skin biopsy and were classified on the basis of histopathological changes. It was observed that there was some disagreement in clinical and histopathological classification. Thus histopathologically there were 20 TT, 9 BT, 7 BB, 6 BL and 58 LL. It appears that skin biopsy may be studied in all cases of leprosy. A combination of clinical features and histological changes in skin biopsy may help in better classification of leprosy.
Assuntos
Hanseníase/classificação , Humanos , Hanseníase/patologiaRESUMO
This paper presents a review of 123 cases of leprosy of different clinical types as regards to their status of cellular immunity. These 123 cases included 41 fresh cases, 18 cases of reaction and 64 cases of leprosy taking antileprosy treatment. Out of 41 untreated cases only 11 turned up for follow up and their lymphoblastic transformation was repeated 4 to 6 months after initiating the treatment. It was observed that cell mediated immunity as expressed in terms of percentage of blast cells is definitely depressed in leprosy, most in LL and least in TT. There is a definite increase in the percentage of blast cells after taking antileprosy treatment. The rise in percentage of blast cells and hence cellular immunity is relatively more in patients treated with Lamprene as compared to those treated with DDS. Reactions also have impact over immunity in leprosy. Thus, most of the patients with ENL show higher values for blast percentage as compared to those with lepra reaction. It appears that serial lymphocyte cultures if done in all cases of leprosy undergoing treatment will help in assessment of individual progress.
Assuntos
Imunidade Celular , Hanseníase/imunologia , Adolescente , Adulto , Criança , Clofazimina/farmacologia , Clofazimina/uso terapêutico , Dapsona/farmacologia , Dapsona/uso terapêutico , Feminino , Humanos , Imunidade Celular/efeitos dos fármacos , Hansenostáticos/farmacologia , Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológico , MasculinoRESUMO
This paper presents a review of 123 cases of leprosy of different clinical types as regards to their status of cellular immunity. These 123 cases included 41 fresh cases, 18 cases of reaction and 64 cases of leprosy taking antileprosy treatment. Out of 41 untreated cases only 11 turned up for follow up and their lymphoblastic transformation was repeated 4 to 6 months after initiating the treatment. It was observed that cell mediated immunity as expressed in terms of percentage of blast cells is definitely depressed in leprosy, most in LL and least in TT. There is a definite increase in the percentage of blast cells after taking antileprosy treatment. The rise in percentage of blast cells and hence cellular immunity is relatively more in patients treated with Lamprene as compared to those treated with DDS. Reactions also have impact over immunity in leprosy. Thus, most of the patients with ENL show higher values for blast percentage as compared to those with lepra reaction. It appears that serial lymphocyte cultures if done in all cases of leprosy undergoing treatment will help in assessment of individual progress.
