Generalized verrucosis: a review of the associated diseases, evaluation, and treatments.

Generalized verrucosis has been described in the past as synonymous with epidermodysplasia verruciformis. It has been shown, however, that epidermodysplasia verruciformis and other genetic or immunodeficiency diseases are just a subset of diffuse infections with human papillomavirus termed "generalized verrucosis." This article defines generalized verrucosis and distinct diseases associated with generalized warts. The indications for histopathologic testing, human papillomavirus typing, and other laboratory analyses and potential treatment options are discussed.

Interaction of topical sulfacetamide and topical dapsone with benzoyl peroxide.

BACKGROUND: A recent study demonstrated evidence of a yellow-orange discoloration of the skin and hair when topical dapsone gel was combined with benzoyl peroxide. This phenomenon had previously been observed by one of us (A.B.F.) when sulfasalazine was combined with benzoyl peroxide. To investigate these interaction phenomena, topical dapsone gel and sulfacetamide sodium lotion were combined with various topical acne treatments, including benzoyl peroxides, clindamycin phosphate, and retinoids. OBSERVATIONS: Products containing benzoyl peroxide produced an orange-brown discoloration when mixed with either sulfacetamide or dapsone. CONCLUSIONS: Knowledge of the chemical reaction between benzoyl peroxide and sulfacetamide and dapsone will help minimize the occurrence of this interaction on our patients' skin.

Effects of gender on physiological responses during submaximal exercise and recovery.

PURPOSE: This investigation was conducted to compare the physiological responses of men and women, both during and following an exercise bout at the same relative submaximal intensity. METHODS: Ten untrained men (20.7+/-0.5 yr, 178.4+/-2.3 cm, 79.6+/-4.8 kg; mean+/-SE) and 10 untrained women (20.3+/-0.3 yr, 163.8+/-2.2 cm, 59.5+/-2.1 kg) cycled for 30 min at 60-65% of their predetermined peak oxygen uptake. Physiological variables were measured before exercise, at 15 and 30 min of exercise, and at 5 and 15 min postexercise. For each variable of interest, a two-way repeated-measures of analysis was used to assess the main effects of gender and time, along with potential interactive effects. RESULTS: Our data revealed that for many variables including HR, relative HR (% peak value), mean arterial pressure, and rectal temperature, men and women responded similarly both during exercise and throughout the recovery period. In contrast, significant (P