Assuntos
Leucemia/epidemiologia , Linfoma/epidemiologia , Adolescente , Fatores Etários , Linfoma de Burkitt/epidemiologia , Criança , Pré-Escolar , Interpretação Estatística de Dados , Feminino , Doença de Hodgkin/epidemiologia , Humanos , Lactente , Recém-Nascido , Leucemia Mieloide Aguda/epidemiologia , Modelos Lineares , Linfoma não Hodgkin/epidemiologia , Masculino , Distribuição de Poisson , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Sistema de Registros , República de Belarus/epidemiologia , Fatores SexuaisAssuntos
Astrocitoma/epidemiologia , Neoplasias Encefálicas/epidemiologia , Neoplasias do Sistema Nervoso Central/epidemiologia , Ependimoma/epidemiologia , Glioma/epidemiologia , Tumores Neuroectodérmicos/epidemiologia , Adolescente , Fatores Etários , Astrocitoma/mortalidade , Neoplasias Encefálicas/mortalidade , Neoplasias do Sistema Nervoso Central/mortalidade , Criança , Pré-Escolar , Interpretação Estatística de Dados , Ependimoma/mortalidade , Feminino , Glioma/mortalidade , Humanos , Lactente , Recém-Nascido , Masculino , Tumores Neuroectodérmicos/mortalidade , Sistema de Registros , República de Belarus/epidemiologia , Fatores Sexuais , Análise de SobrevidaRESUMO
Evaluation of nucleolar organizer regions (Ag-NOR) and mitotic regimen (MR) of normal lymph nodes and those with follicular hyperplasia (n = 10) as well as non-Hodgkin's lymphomas (NHL) of low and high grade of malignancy (n = 40) is performed in 50 cytograms stained after Pappenheim and with colloidal silver. Correlation of indices of MR and Ag-NOR with morphologic grade of malignancy of NHL was found. For blastic forms of NHL higher Ag-NOR, lager number of mitoses and their pathologic forms are characteristic compared with cytic ones (8.59 +/- 3.15; 13.60 +/- 4.9/1000; 37.9% and 2.06 +/- 0.63; 2.10 +/- 2.45/1000; 23.8%, respectively, p < 0.001). Calculation of Ag-NOR allowed to distinguish NHL of low grade and high grade of malignancy containing 1.13 to 3.68 and 4.76 to 18.22 Ag-grains per nucleus, respectively (the difference is statistically significant). This is important for differential diagnosis of "small cell" types of the tumor. Significant correlation between the number of Ag-NOR and mitotic activity of NHL is found (r = 0.772; p < 0.001) indicating that the number of Ag-NOR reflects cell kinetics of the tumor. The results of the activity evaluation of Ag-NOR and MR of cells may be used in differential diagnosis, gradation and definition of proliferative NHL status.
Assuntos
Linfoma não Hodgkin/patologia , Mitose/fisiologia , Região Organizadora do Nucléolo/ultraestrutura , Biópsia , Linfoma de Burkitt/patologia , Estudos de Casos e Controles , Diagnóstico Diferencial , Humanos , Modelos Lineares , Estadiamento de Neoplasias , Coloração pela PrataRESUMO
The mitotic regimen of non-Hodgkin's lymphomas (n = 86) and of reactive follicular hyperplasia (n = 14) has been studied. A correlation between the parameters of mitotic regimen and morphologic degradation of malignant lymphomas has been revealed. Blastic forms of lymphomas were found to be characterized by the highest mitotic activity with a greater number and variety of forms of pathologic mitoses (p < 0.001). The frequency of mitoses in lymphomas of low malignancy was found to be reliably reduced in comparison with that in follicular hyperplasia (p < 0.01). The results of assessing the mitotic regimen are recommended to be used for the differential diagnosis and subclassification of non-Hodgkin's lymphomas.
