[COVID-19 and cerebral stroke]. / COVID-19 i tserebral'nyi insul't.

OBJECTIVE: To analyze mortality rates, rehabilitation potential, and features of the course of stroke in patients with COVID-19. MATERIAL AND METHODS: The study included 50 patients in the acute period of stroke who were diagnosed with a new coronavirus infection during treatment. For comparison, we selected a group of 50 patients who had stroke during this period. RESULTS: In the study group, the virus was identified in 38 (76%) patients by polymerase chain reaction (PCR). The onset of symptoms of acute respiratory viral infection or fever was observed on average 11 days after the onset of neurological symptoms. Only in 10 (20%) patients, a PCR smear showed a positive result in the first 24 hours after the development of a stroke. In the main group, death was observed in 30% (n=15) of cases; in the comparison group - in 6% (n=3) cases. Also, in the main group of patients, a lower degree of recovery of impaired neurological functions was noted on the National Institutes of Health Stroke Scale (NIHSS). At discharge from the hospital, 33 (66%) patients had moderate and severe disabilities according to the modified Rankin scale (3-4 points). The differences were statistically significant, as in the main group there was more pronounced disability than in the control group. Lymphopenia was noted in 26 (52%) patients of the main group on admission. CONCLUSION: Increased mortality rate, decreased recovery of neurological functions and severe disabilities are observed in the group of patients with stroke who were infected by COVID-19. Lymphopenia in a patient with stroke can serve as a prognostic marker of the possible presence of COVID-19 and the degree of lung tissue damage.

[The reasons for the resistance of Vibrio cholerae to diagnostic phages]. / Prichiny ustoichivosti kholernykh vibrionov k diagnosticheskim fagam.

Phage resistance of 225 strains of cholera germs of O1 group obtained from different countries in 1988-1992 has been analyzed. Change of sensitivity to diagnostic phages was mostly connected with the decrease or loss of agglutinability in cholera sera. Phage resistance is rather conditioned by the change of the surface structures of the cell and by further change of phage reception zones. The increase in the number of strains sensitive to diagnostic phages after 6-12 months of storage evidenced for stabilization of cell wall structures and increase of their viability under relatively favourable conditions of storage.

[A study of the biological properties of cholera phages and strains of El-Tor vibrions isolated from the external environment in Donetsk]. / Izuchenie biologicheskikh svoistv kholernykh fagov i shtammov vibrionov El-Tor vydelennykh iz vneshnei sredy Donetska.

Choleric phages were identified in 2 out of 44 samples of Donetsk sewage. Biological properties of phages were characterized.

[The lysogeny of Vibrio parahaemolyticus of serovar O4:K12]. / Lizogeniia paragemoliticheskikh vibrionov serovara O4:K12.

Lysogeny has been first established in strains of parahemolytic vibrios of serovar O4:K12. Moderate phages belonged to morphological group IV by home A. S. Tikhonenko's classification and were presented by one serological type. No correlation has been revealed between sensitivity to moderate phages of parahemolytic vibrios and specificity of "O"- or "K"-serotypes.