RESUMO
We studied the effects of combined chemotherapy with doxorubicin/docetaxel on erythroid and granulocytic hematopoietic lineages with particular attention focused on their recovery in patients with stages III-IV breast cancer. Intensification of differentiation of erythroid and granulocytic CFU (even under conditions of their suppressed proliferation) provided the increase in the content of mature and morphologically differentiated elements in the bone marrow and peripheral blood. High proliferative activity of erythroid and granulomonocytic precursors resulted from enhanced production of hematopoiesis-stimulating activities by microenvironment elements.
Assuntos
Antineoplásicos/uso terapêutico , Neoplasias da Mama/tratamento farmacológico , Docetaxel/uso terapêutico , Doxorrubicina/uso terapêutico , Eritropoese/efeitos dos fármacos , Leucopoese/efeitos dos fármacos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Medula Óssea/metabolismo , Linhagem da Célula/efeitos dos fármacos , Eritrócitos/citologia , Feminino , Fator Estimulador de Colônias de Granulócitos/metabolismo , Granulócitos/citologia , HumanosRESUMO
We studied myelotoxicity of modern schemes of chemotherapy for breast cancer (docetaxel/doxorubicin and cyclophosphamide/doxorubicin/5-fluorouracil) towards granulocytopoiesis, the mechanisms determining the differences of hematological effects of these schemes, and the efficiency of correction of the observed changes with granulocyte CSF (filgrastim). Granulocytopoiesis stimulation with filgrastim during the treatment with docetaxel/doxorubicin combination was more pronounced than during cyclophosphamide/doxorubicin/5-fluorouracil therapy. The observed differences were found at all levels of granulocyte lineage organization (central and peripheral), which is related to different effects of the cytostatic substances used in the proposed protocols on the structures controlling hemopoiesis.
Assuntos
Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/metabolismo , Filgrastim/uso terapêutico , Granulócitos/citologia , Granulócitos/efeitos dos fármacos , Ciclofosfamida/uso terapêutico , Doxorrubicina/uso terapêutico , Feminino , Fluoruracila/uso terapêutico , Fator Estimulador de Colônias de Granulócitos/metabolismo , HumanosRESUMO
The degree of heart rate (HR) and of duration PP, PT and TP elements electrocardiogram (ECG) before and after physical exercises (PE) depends on their value in the control, in healthy young girls (n = 21), aged 18.1 ± 0.7 years, body weight 56.5 ± 4.0 kg. The 300 cardiocycles by ECG at II standard lead were registered. Ð ower of PE was 1 W/kg. The growth of the HR after PE at the time of depolarization and repolarization (PT interval) remains practically unchanged, whereas the duration of the isopotential state of the myocardium (segment TP) is revealed. The PP intervals of long duration are shortened by 60%, low duration - by 30 %. The variability of PP interval in control due to the variability of the TP segment, in the experience of the PT interval was found.
