[The significance of intercellular interrelations in the diagnosis of immunopathological states in patients with chronic neurological infections with a course of allergic disorders]. / Znachenie mezhkletochnykh vzaimootnoshenii v diagnostike immunopatologicheskikh sostoianii bol'nykh khronicheskimi neiroinfektsiiami, protekaiushchimi s allergicheskimi narusheniiami.

As many as 120 patients with different nosological forms of neuroinfections (encephalitis, encephalomyelitis, chorioependymitis and cerebral arachnoiditis) associated with allergic disturbances were examined by clinical and immunological methods. In addition to the common measurements of the relative and absolute content of T, B and 0 cells, cerebral antibodies and circulating immune complexes, the degree of the T component deficiency was calculated as compared to that in healthy persons as were intercellular and populational relations, which characterized individual immune responsiveness. It has been discovered that the populational relations undergo changes in initial manifestations of immune deficiency, becoming more remarkable as the pathological process progresses. The authors point to the necessity of analyzing the immunogram in patients placed under observation with a purpose of early diagnosis of immune imbalance that arises, and of defining the leading immunopathological mechanism to carry out more adequate and goal-oriented correction of immune disorders.

[Trans-cerebral electrophoresis of L-DOPA in the complex treatment of parkinsonism]. / Transtserebral'nyi élektroforez L-DOPA v kompleksnom lechenii parkinsonizma.

Based on the established electrophoretic mobility of L-DOPA and on pathogenetic assumptions, the authors carried out multiple modality treatment employing transcerebral L-DOPA electrophoresis in 48 patients with postencephalic and atherosclerotic parkinsonism. The majority of patients (43 subjects) showed an improvement of various degrees, particularly when rigidity and oligo- and bradykinesia were predominant in the clinical picture of the disease. Of the 48 patients treated, 29 received L-DOPA per os and 19 patients were given low drug doses. The therapeutic effect persisted from 2 weeks to 2-3 months.