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Exp Dermatol ; 23(10): 769-71, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-25078048

RESUMO

Deletion of two members of the late cornified envelope (LCE) family, LCE3B and LCE3C (LCE3C_LCE3B-del), has been identified as risk factor for psoriasis with a possible role in skin barrier function. Moreover, genetic interaction between LCE3C_LCE3B-del and HLA-C*06, located in the psoriasis susceptibility regions 4 and 1 (PSORS4 and 1), has been reported in several populations. Because of high linkage disequilibrium between the PSORS1 genes HLA-C*06 and corneodesmosin (CDSN), both genes are potentially involved in psoriasis. As corneodesmosin and LCE proteins are both constituents of the stratum corneum, we investigated potential direct protein-protein interactions between six LCE proteins and two corneodesmosin sequence variants. Partial colocalization of LCE2 and CDSN was observed in normal and psoriasis skin using immunofluorescence microscopy. Co-expression of eCFP-LCE and mRFP-CDSN proteins in COS-1 cells and human adult keratinocytes, and GST pull-down results did not provide evidence for direct interactions between LCE proteins and CDSN variants.


Assuntos
Proteínas Ricas em Prolina do Estrato Córneo/metabolismo , Glicoproteínas/metabolismo , Animais , Células COS , Chlorocebus aethiops , Proteínas Ricas em Prolina do Estrato Córneo/química , Proteínas Ricas em Prolina do Estrato Córneo/genética , Variação Genética , Glicoproteínas/química , Glicoproteínas/genética , Humanos , Peptídeos e Proteínas de Sinalização Intercelular , Queratinócitos/metabolismo , Desequilíbrio de Ligação , Mapeamento de Interação de Proteínas , Psoríase/genética , Psoríase/metabolismo , Fatores de Risco , Pele/metabolismo
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