RESUMO
OBJECTIVE: To find out whether there is considerable influence on second trimester serum concentrations owing to the rhesus status. STUDY DESIGN: This retrospective cohort study was performed at the Perinatology Unit of the GATA Haydarpasa Teaching Hospital. During the study interval, 2265 pregnancies met inclusion criteria. The blood samples were collected in 117 pregnancies with a maternal rhesus-negative blood group status. The control group consisted of 2148 pregnancies with a maternal rhesus-positive blood group status. Statistical analysis was performed by SPSS 11.0 statistical software. RESULTS: Pregnancies with a maternal rhesus-negative blood group status were identified in 117 patients. The overall prevalence of pregnancies with a maternal rhesus-negative blood group status were 5.1% in our study. Only unconjugated estriol multiples of the median values were significantly decreased in rhesus-negative women (P<0.001). Alpha-fetoprotein and human chorionic gonadotrophin multiples of the median values did not differ significantly (P>0.05). CONCLUSION: We conclude that if second trimester screening test to be used in Rh negative pregnancies, either the corrected value should be referred or double test result should be considered ignoring the unconjugated estriol result. Another option is the first trimester Down syndrome screening test.
Assuntos
Síndrome de Down/diagnóstico , Programas de Rastreamento , Diagnóstico Pré-Natal , Isoimunização Rh/diagnóstico , Adulto , Gonadotropina Coriônica/sangue , Síndrome de Down/epidemiologia , Síndrome de Down/prevenção & controle , Estriol/sangue , Feminino , Humanos , Recém-Nascido , Valor Preditivo dos Testes , Gravidez , Valores de Referência , Isoimunização Rh/sangue , Isoimunização Rh/epidemiologia , Turquia , alfa-Fetoproteínas/metabolismoRESUMO
The general term "retinoids" refers to both naturally occurring as well as synthetic compounds which exhibit biological activity similar to vitamin A (retinol). Vitamin A and its two metabolites, retinaldehyde and retinoic acid, are fat-soluble unsaturated isoprenoids necessary for the growth, differentiation and maintenance of epithelial tissues. In this study, we have synthesized thiazolidinedione/imidazolidinedione compounds as retinoids. Their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels and superoxide anion formation were determined.
Assuntos
Antioxidantes/síntese química , Antioxidantes/farmacologia , Retinoides/síntese química , Retinoides/farmacologia , Tiazóis/síntese química , Tiazóis/farmacologia , Animais , Grupo dos Citocromos c/química , Técnicas In Vitro , Indicadores e Reagentes , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Microssomos Hepáticos/efeitos dos fármacos , Microssomos Hepáticos/metabolismo , NADP/metabolismo , Ratos , Superóxidos/metabolismoRESUMO
A new series of flavonyl compounds (1-10) was prepared and tested for their insulinotropic activities in INS-1 cells. Compounds 2, 5 and 6 (at higher concentrations) and compounds 3 and 7-10 were able to increase insulin release in the presence of 5.6 mmol/l glucose at both concentrations used (1 and 10 micrograms/ml).
