Two-Capacitor Direct Interface Circuit for Resistive Sensor Measurements.

Direct interface circuits (DICs) avoid the need for signal conditioning circuits and analog-to-digital converters (ADCs) to obtain digital measurements of resistive sensors using only a few passive elements. However, such simple hardware can lead to quantization errors when measuring small resistance values as well as high measurement times and uncertainties for high resistances. Different solutions to some of these problems have been presented in the literature over recent years, although the increased uncertainty in measurements at higher resistance values is a problem that has remained unaddressed. This article presents an economical hardware solution that only requires an extra capacitor to reduce this problem. The circuit is implemented with a field-programmable gate array (FPGA) as a programmable digital device. The new proposal significantly reduces the uncertainty in the time measurements. As a result, the high resistance errors decreased by up to 90%. The circuit requires three capacitor discharge cycles, as is needed in a classic DIC. Therefore, the time to estimate resistance increases slightly, between 2.7% and 4.6%.

Reducing Measurement Time in Direct Interface Circuits for Resistive Sensor Readout.

Direct Interface Circuits (DICs) carry out resistive sensor readings using a resistance-to-time-to-digital conversion without the need for analog-to-digital converters. The main advantage of this approach is the simplicity involved in designing a DIC, which only requires some additional resistors and a capacitor in order to perform the conversion. The main drawback is the time needed for this conversion, which is given by the sum of up to three capacitor charge times and their associated discharge times. This article presents a modification of the most widely used estimation method in a resistive DIC, which is known as the Two-Point Calibration Method (TPCM), in which a single additional programmable digital device pin in the DIC and one extra measurement in each discharge cycle, made without slowing down the cycle, allow charge times to be reduced more than 20-fold to values around 2 µs. The new method designed to achieve this reduction only penalizes relative errors with a small increase of between 0.2% and 0.3% for most values in the tested resistance range.

Quasi Single Point Calibration Method for High-Speed Measurements of Resistive Sensors.

Direct interface circuits are a simple, inexpensive alternative for the digital conversion of a sensor reading, and in some of these circuits only passive calibration elements are required in order to carry out this conversion. In the case of resistive sensors, the most accurate methods of calibration, namely two-point calibration method (TPCM) and fast calibration methods I and II (FCMs I and II), require two calibration resistors to estimate the value of a sensor. However, although FCMs I and II considerably reduce the time necessary to estimate the value of the sensor, this may still be excessive in certain applications, such as when making repetitive readings of a sensor or readings of a large series of sensors. For these situations, this paper proposes a series of calibration methods that decrease the mean estimation time. Some of the proposed methods are based on the TPCM and quasi single-point calibration methods, while others make the most of the advantages of FCM II and fast quasi single-point calibration methods. In general, the proposed methods significantly reduce estimation times in exchange for a small increase in errors. To validate the proposal, a circuit with a Xilinx XC3S50AN-4TQG144C FPGA has been designed and resistors in the range (267.56 Ω, 7464.5 Ω) have been measured. For 20 repetitive measurements, the proposed methods achieve time reductions of up to 61% with a relative error increase of only 0.1%.

Fast Calibration Methods for Resistive Sensor Readout Based on Direct Interface Circuits.

A simple method to measure the resistance of a sensor and convert it into digital information in a programmable digital device is by using a direct interface circuit. This type of circuit deduces the value of the resistor based on the discharge time through it for a capacitor of a known value. Moreover, the discharge times of this capacitor should be measured through one or two resistors with known values in order to ensure that the estimate is not dependent on certain parameters that change with time, temperature, or aging. This can slow down the conversion speed, especially for high resistance values. To overcome this problem, we propose a modified process in which part of the discharge, which was previously performed through the resistive sensor only, is only conducted with the smallest calibration resistor. Two variants of this operation method, which differ in the reduction of the total time necessary for evaluation and in the uncertainty of the measurements, are presented. Experiments carried out with a field programmable gate array (FPGA); using these methodologies achieved reductions in the resistance conversion time of up to 55%. These reductions may imply an increase in the uncertainty of the measurements; however, the tests carried out show that with a suitable choice of parameters, the increases in uncertainty, and therefore errors, may be negligible compared to the direct interface circuits described in the literature.

High-Accuracy Readout Electronics for Piezoresistive Tactile Sensors.

The typical layout in a piezoresistive tactile sensor arranges individual sensors to form an array with M rows and N columns. While this layout reduces the wiring involved, it does not allow the values of the sensor resistors to be measured individually due to the appearance of crosstalk caused by the nonidealities of the array reading circuits. In this paper, two reading methods that minimize errors resulting from this phenomenon are assessed by designing an electronic system for array reading, and the results are compared to those obtained using the traditional method, obviating the nonidealities of the reading circuit. The different models were compared by testing the system with an array of discrete resistors. The system was later connected to a tactile sensor with 8 × 7 taxels.

Accuracy and Resolution Analysis of a Direct Resistive Sensor Array to FPGA Interface.

Resistive sensor arrays are formed by a large number of individual sensors which are distributed in different ways. This paper proposes a direct connection between an FPGA and a resistive array distributed in M rows and N columns, without the need of analog-to-digital converters to obtain resistance values in the sensor and where the conditioning circuit is reduced to the use of a capacitor in each of the columns of the matrix. The circuit allows parallel measurements of the N resistors which form each of the rows of the array, eliminating the resistive crosstalk which is typical of these circuits. This is achieved by an addressing technique which does not require external elements to the FPGA. Although the typical resistive crosstalk between resistors which are measured simultaneously is eliminated, other elements that have an impact on the measurement of discharge times appear in the proposed architecture and, therefore, affect the uncertainty in resistance value measurements; these elements need to be studied. Finally, the performance of different calibration techniques is assessed experimentally on a discrete resistor array, obtaining for a new model of calibration, a maximum relative error of 0.066% in a range of resistor values which correspond to a tactile sensor.

Improved Circuits with Capacitive Feedback for Readout Resistive Sensor Arrays.

One of the most suitable ways of distributing a resistive sensor array for reading is an array with M rows and N columns. This allows reduced wiring and a certain degree of parallelism in the implementation, although it also introduces crosstalk effects. Several types of circuits can carry out the analogue-digital conversion of this type of sensors. This article focuses on the use of operational amplifiers with capacitive feedback and FPGAs for this task. Specifically, modifications of a previously reported circuit are proposed to reduce the errors due to the non-idealities of the amplifiers and the I/O drivers of the FPGA. Moreover, calibration algorithms are derived from the analysis of the proposed circuitry to reduce the crosstalk error and improve the accuracy. Finally, the performances of the proposals is evaluated experimentally on an array of resistors and for different ranges.

Smart Capture Modules for Direct Sensor-to-FPGA Interfaces.

Direct sensor-digital device interfaces measure time dependent variables of simple circuits to implement analog-to-digital conversion. Field Programmable Gate Arrays (FPGAs) are devices whose hardware can be reconfigured to work in parallel. They usually do not have analog-to-digital converters, but have many general purpose I/O pins. Therefore, direct sensor-FPGA connection is a good choice in complex systems with many sensors because several capture modules can be implemented to perform parallel analog data acquisition. The possibility to work in parallel and with high frequency clock signals improves the bandwidth compared to sequential devices such as conventional microcontrollers. The price to pay is usually the resolution of measurements. This paper proposes capture modules implemented in an FPGA which are able to perform smart acquisition that filter noise and achieve high precision. A calibration technique is also proposed to improve accuracy. Resolutions of 12 effective number of bits are obtained for the reading of resistors in the range of an example piezoresistive tactile sensor.

Diffraction-limited step-zoom telescope by image restoration.

The design of a step-zoom telescope and its ability to achieve a diffraction-limited performance is explored. The basic idea is to include digital postprocessing to compensate for changes in the modulation transfer function of the system, assuming the knowledge of the range to the object. The instrument is conformed of a two-mirror telescope, two lenses, and a detector. High-quality images and a zoom telescope that ranges from 22 to 61 f-number is achieved by moving the primary mirror and two lenses. The preliminary calculations for the design process and a simulation that shows the performance of the step-zoom telescope are described.

A new model based on adaptation of the external loop to compensate the hysteresis of tactile sensors.

This paper presents a novel method to compensate for hysteresis nonlinearities observed in the response of a tactile sensor. The External Loop Adaptation Method (ELAM) performs a piecewise linear mapping of the experimentally measured external curves of the hysteresis loop to obtain all possible internal cycles. The optimal division of the input interval where the curve is approximated is provided by the error minimization algorithm. This process is carried out off line and provides parameters to compute the split point in real time. A different linear transformation is then performed at the left and right of this point and a more precise fitting is achieved. The models obtained with the ELAM method are compared with those obtained from three other approaches. The results show that the ELAM method achieves a more accurate fitting. Moreover, the involved mathematical operations are simpler and therefore easier to implement in devices such as Field Programmable Gate Array (FPGAs) for real time applications. Furthermore, the method needs to identify fewer parameters and requires no previous selection process of operators or functions. Finally, the method can be applied to other sensors or actuators with complex hysteresis loop shapes.

Influence of Errors in Tactile Sensors on Some High Level Parameters Used for Manipulation with Robotic Hands.

Tactile sensors suffer from many types of interference and errors like crosstalk, non-linearity, drift or hysteresis, therefore calibration should be carried out to compensate for these deviations. However, this procedure is difficult in sensors mounted on artificial hands for robots or prosthetics for instance, where the sensor usually bends to cover a curved surface. Moreover, the calibration procedure should be repeated often because the correction parameters are easily altered by time and surrounding conditions. Furthermore, this intensive and complex calibration could be less determinant, or at least simpler. This is because manipulation algorithms do not commonly use the whole data set from the tactile image, but only a few parameters such as the moments of the tactile image. These parameters could be changed less by common errors and interferences, or at least their variations could be in the order of those caused by accepted limitations, like reduced spatial resolution. This paper shows results from experiments to support this idea. The experiments are carried out with a high performance commercial sensor as well as with a low-cost error-prone sensor built with a common procedure in robotics.

Common-pull, multiple-push, vacuum-activated telescope mirror cell.

A new concept for push-pull active optics is presented, where the push-force is provided by means of individual airbag type actuators and a common force in the form of a vacuum is applied to the entire back of the mirror. The vacuum provides the pull-component of the system, in addition to gravity. Vacuum is controlled as a function of the zenithal angle, providing correction for the axial component of the mirror's weight. In this way, the push actuators are only responsible for correcting mirror deformations, as well as for supporting the axial mirror weight at the zenith, allowing for a uniform, full dynamic-range behavior of the system along the telescope's pointing range. This can result in the ability to perform corrections of up to a few microns for low-order aberrations. This mirror support concept was simulated using a finite element model and was tested experimentally at the 2.12 m San Pedro Mártir telescope. Advantages such as stress-free attachments, lighter weight, large actuator area, lower system complexity, and lower required mirror-cell stiffness could make this a method to consider for future large telescopes.

Three realizations and comparison of hardware for piezoresistive tactile sensors.

Tactile sensors are basically arrays of force sensors that are intended to emulate the skin in applications such as assistive robotics. Local electronics are usually implemented to reduce errors and interference caused by long wires. Realizations based on standard microcontrollers, Programmable Systems on Chip (PSoCs) and Field Programmable Gate Arrays (FPGAs) have been proposed by the authors for the case of piezoresistive tactile sensors. The solution employing FPGAs is especially relevant since their performance is closer to that of Application Specific Integrated Circuits (ASICs) than that of the other devices. This paper presents an implementation of such an idea for a specific sensor. For the purpose of comparison, the circuitry based on the other devices is also made for the same sensor. This paper discusses the implementation issues, provides details regarding the design of the hardware based on the three devices and compares them.

Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry.

A chronic adverse reaction may occur in some instances of drug-induced liver injury (DILI), even despite drug cessation. In our study, we obtained records from a Spanish registry and evaluated cases of DILI with biochemical evidence of long-term damage. Chronic outcome was defined as a persistent biochemical abnormality of hepatocellular pattern of damage more than 3 months after drug withdrawal or more than 6 months after cholestatic/mixed damage. Data on 28 patients with a chronic clinical evolution (mean follow-up 20 months) between November 1995 and October 2005 were retrieved (18 female; overall mean age 55 yr) and accounted for 5.7% of total idiosyncratic DILI cases (n = 493) submitted to the registry. The main drug classes were cardiovascular and central nervous system (28.5% and 25%, respectively), which, in contrast, represented only 9.8% and 13%, respectively, of all DILI cases. The most frequent causative drugs were amoxicillin-clavulanate (4 of 69 cases), bentazepam (3 of 7 cases), atorvastatin (2 of 7 cases), and captopril (2 of 5 cases). Patients with cholestatic/mixed injury (18 of 194 cases [9%]) were more prone to chronicity than patients with hepatocellular injury (10 of 240 cases; P < .031). In the case of chronic hepatocellular injury, 3 patients progressed to cirrhosis and 2 to chronic hepatitis. In the cholestatic/mixed group, liver biopsy indicated cirrhosis in 1 patient and ductal lesions in 3 patients. In conclusion, cholestatic/mixed type of damage is more prone to become chronic while, in the hepatocellular pattern, the severity is greater. Cardiovascular and central nervous system drugs are the main groups leading to chronic liver damage.

Determinants of the clinical expression of amoxicillin-clavulanate hepatotoxicity: a prospective series from Spain.

Amoxicillin-clavulanate (AC) hepatotoxicity has been reported to exhibit a higher predominance of cholestatic types of damage, especially in males. However, the determinants of its clinical expression are unknown. This study prospectively evaluated the profile of AC hepatotoxicity. Data on all cases of hepatotoxicity reported to the Spanish Registry attributed to AC and assessed as definite or probable on the Council for International Organizations of Medical Sciences (CIOMS) scale were collated and compared to published case series. Hepatotoxicity related to amoxicillin-clavulanate was identified in 69 patients (36 males; mean age 56 years) representing 14% of all cases of hepatotoxicity submitted to the Registry. There was an overall sex distribution and the predominant pattern of lesion was hepatocellular (36%) which occurred at a shorter duration of treatment (P < .03). Mean time lapse between therapy initiation and jaundice onset was 16 days. Late onset of symptoms following end of treatment occurred in half the cases. Multiple logistic regression analysis identified advancing age as the factor associated with the development of cholestatic/mixed type of injury (odds ratio for an age interval for 1 year: 1.045 [95% CI = 1.013-1.078; P = .005). An unfavorable outcome was seen in 7% of patients. In conclusion, age is the most important determinant in the biochemical expression of AC hepatotoxicity; younger age is associated with cytolytic damage and shorter treatment duration, whereas cholestatic/mixed type of damage is related to older age and prolonged AC therapy.

Manejo de la infección respiratoria aguda en un hospital de niños / The management of acute respiratory infection in the children hospital

Se realizó un estudio prospectivo, longitudinal y analítico para determinar el manejo de Insuficiencia Respiratoria Aguda (IRA), en el Hospital Robert Reid Cabral (HRRC), República Dominicana. La muestra la constituyó 100 niños menores de 5 años con IRA durante el período agosto 1989-mayo 1990. El estudio reveló: 51 de ellos tenían menos de 1 año de edad; 59.0//fue diagnosticado IRA leve; 36.0//moderada; 5.0//grave. 74 de los 100 fueron manejados con antibióticos: 47.3//(35) en IRA leve; 46.0//(34) en moderada y 6.70//(5) en grave. 37.80//con penicilina G procaínica; 23//amoxicilina. La duración de la antibioterapia más frecuente fue 6-8 días con 38.2//; siendo esta manejada por médico pediatra en 81.0//seguido del residente de primer año con 12.2//. El uso de antibiótico en IRA leve fue notable, por lo que concluimos que hubo un manejo indiscriminado, entendiendo que este es exclusivamente sintomático

Manejo de infección respiratoria aguda (IRA) en la consulta externa del Hospital Robert Reid Cabral / Handleing of acute respiratory infection in the extern consult at Hospital Robert Reid Cabral

Se realizó un estudio prospectivo transversal en una muestra de 100 niños, menores de 5 años con Infección Respiratoria Aguda (IRA) que acudieron a la consulta externa y a la emergencia durante todo el día en los meses de agosto 1989 a mayo 1990. En el Hospital Robert Reid Cabral de Santo Domingo; República Dominicana. Encontrándose que la IRA más frecuente, fue la IRA Leve (no complicada) y que el 59 por ciento de estos niños con IRA no complicada fueron tratados con antibióticos