RESUMO
A new diglucoside having a 5-methylchromone moiety was isolated from a commercial sample of Cape aloe, the dried exudate from Aloe ferox Miller, and named aloeresin I. Its structure was established as 1 on the basis of spectral and chemical evidence. Aloeresin I (1) (1 micromol/cm2) reduces in vivo the oedematous response (39 %) induced by Croton oil in the mouse ear with the same potency as aloesin, one of the most abundant Cape aloe constituents, and to a higher extent than aloeresin H (2). Indomethacin (0.3 micromol/cm2), the reference anti-inflammatory compound, provokes 61 % oedema inhibition.
Assuntos
Aloe , Anti-Inflamatórios não Esteroides/farmacologia , Cromonas/farmacologia , Dissacarídeos/farmacologia , Fitoterapia , Animais , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/uso terapêutico , Cromonas/administração & dosagem , Cromonas/uso terapêutico , Óleo de Cróton , Dissacarídeos/administração & dosagem , Dissacarídeos/uso terapêutico , Edema/induzido quimicamente , Edema/diagnóstico , Masculino , Camundongos , Camundongos Endogâmicos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêuticoRESUMO
Two new compounds, 10-O-beta-D-glucopyranosyl aloenin (4) and 8-C-beta-D-glucopyranosyl-7-O-methyl-(R)-aloesol (6), were isolated from a commercial sample of Kenya aloe together with the known products aloenin (2), aloenin 2'-p-coumaroyl ester (3), aloenin aglycone (1), orcinol and acetylorcinol. All structures were determined or confirmed by spectral analyses.
