RESUMO
In two groups of women--one group of 12 normal-mammary-gland controls and another group of 10 idiopathic galactorrhoea patients--we determined the blood concentration of serotonin and prolactin. The obtained data show no significant differences between the studied groups either in serotonin or prolactin levels i.e., serotonin is not implied in the pathogeny of idiopathic galactorrhoea. The data are confirming our previous results concerning the functional correlations between the serotonin system and prolactin release, as well as the data obtained by other authors on the normal values of prolactin in idiopathic galactorrhoea.
Assuntos
Galactorreia/sangue , Transtornos da Lactação/sangue , Prolactina/sangue , Serotonina/sangue , Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , GravidezRESUMO
By spectrofluorimetric method there was followed the blood and cerebral serotonin content in different species of mammalians: in 28 women, from the venous whole blood collected by cubital puncture, and in 20 cows, from the jugular whole blood. In 90 female rats the serotonin content from hypothalamus, rhinencephalon, mesencephalon, and sensorimotor cortex was determined. The obtained data show that in the course of labour in both species the blood serotonin concentration is decreased, returning to its initial values after delivery. The serotonin concentration in cows is 10--15 times higher than in women. As concerns the serotonin values in the cerebral nuclei through pregnancy, a progressive and significant increase of its content was noted in the hypothalamus, rhinencephalon, and mesencephalon, but not in the cerebral cortex. It reaches its maximum concentration at the end of pregnancy. It was concluded that during pregnancy a reduction of serotonin release processes is produced, which can signify a lower functional level of the serotoninergic structures implied in the regulation of the reproductive functions. The data are interpreted in the light of the particular endocrine state existing through pregnancy, attributing to serotonin a role in the functioning of PIF-prolactin system.
Assuntos
Trabalho de Parto , Gravidez , Serotonina/metabolismo , Animais , Encéfalo/metabolismo , Bovinos , Feminino , Humanos , Prenhez , Ratos , Serotonina/sangue , Serotonina/líquido cefalorraquidianoRESUMO
PIP: PGs (prostaglandins), a group of chemically related substances, are fatty acid derivatives found in the extracts of several mammal organs and tissues. With a high biologic potential and certain prevalently local, pharmacodynamic effects, they can be classified as hormones, coenzymes, or mediatory substances. The generic term of PG indicates the source from which they were 1st extracted, i.e., the male genitalia and their secretions. (Author's)^ieng
