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Cancer Res ; 71(12): 4096-105, 2011 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-21593193

RESUMO

Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C(-/-) mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis.


Assuntos
Moléculas de Adesão Celular/fisiologia , Imunoglobulinas/fisiologia , Neoplasias Pulmonares/secundário , Melanoma/patologia , Animais , Células CHO , Moléculas de Adesão Celular/análise , Moléculas de Adesão Celular/antagonistas & inibidores , Linhagem Celular Tumoral , Movimento Celular , Cricetinae , Cricetulus , Células Endoteliais/fisiologia , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Invasividade Neoplásica
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