RESUMO
We report a facial tumor that was proven to be a metastatic mesothelioma. The diagnosis was not established pre-mortem. The patient died shortly after the facial biopsy, and an autopsy revealed a large pleural-based mass which had the gross appearance typical of a mesothelioma. Electron microscopic examination of tissue from the pleural tumor was diagnostic for mesothelioma. The patient had extensive visceral metastatic disease. Inclusion of this entity in the differential diagnosis of certain cutaneous tumors is important, in part because this lesion may be confused with angiosarcoma, particularly when it occurs in the skin of the face or head in older patients.
Assuntos
Neoplasias Faciais/secundário , Mesotelioma/secundário , Neoplasias Pleurais/patologia , Neoplasias Cutâneas/secundário , Adenocarcinoma/patologia , Diagnóstico Diferencial , Neoplasias Faciais/patologia , Hemangiossarcoma/patologia , Humanos , Imuno-Histoquímica , Masculino , Mesotelioma/patologia , Microscopia Eletrônica , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologiaRESUMO
A method of standardizing mitotic counts is described. This provisional approach, which expresses mitoses as a percentage of breast cancer cells present, holds the promise of facilitating interlaboratory agreement as well as providing a measure of tumor cellularity, probably an independent prognostic indicator in its own right. We suggest that this approach or one similar to it will maximize the evaluation and quantitation of proliferative activity from routinely available histologic material. Furthermore, the method is accomplished with little added effort beyond the customary histologic evaluation.
Assuntos
Neoplasias da Mama/patologia , Técnicas Citológicas/normas , Índice Mitótico , Contagem de Células , HumanosRESUMO
We have reported a case of eruptive vellus hair cysts, a rare type of acneiform eruption. Patients with unusual or refractory acneiform eruptions may have any of a variety of non-acne-vulgaris lesions. For this reason, biopsy and culture of these lesions may be helpful in establishing a correct diagnosis and determining proper treatment.
Assuntos
Acne Vulgar/etiologia , Cisto Epidérmico/complicações , Acne Vulgar/tratamento farmacológico , Adulto , Diagnóstico Diferencial , Cisto Epidérmico/diagnóstico , Cisto Epidérmico/patologia , Feminino , Cabelo , Humanos , Tretinoína/uso terapêuticoRESUMO
The objective of this study was to determine the short- and long-term radiographic, physiologic and histologic changes elicited in the lung of rabbits following the aspiration of commonly used radiographic contrast agents. All agents used, including nonionic agents, caused radiographically evident pulmonary edema which cleared by 24 hours. The contrast materials with higher osmolality, viscosity, and iodine content elicited the greatest physiologic and pathologic changes. No differences were found between an ionic and a nonionic agent with similar viscosities and iodine content, despite a lower osmolality in the nonionic agent. No contrast agent is innocuous when introduced into the lung.
