1.
Nat Genet
; 48(5): 497-9, 2016 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26974008
RESUMO
There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.