[Radionuclide study of liver function in polycythemia vera and other types of polycythemia]. / Radionuklidnoe issledovanie funktsii pecheni pri istinnoi politsitemii i nekotorykh vidakh poliglobulii.

Clinico-laboratory and radionuclide (radio-hepatography with 131I-rose bengal and liver scanning with 198Au colloid solution) investigation of liver function was performed in 110 patients with polycythemia vera during exacerbation, in 16 patients with symptomatic erythrocytosis (10--chronic pulmonary disease, 3--polycystic kidney, 2--obesity, 1--peptic ulcer), and in 11 patients with a polycythemic form of myelofibrosis. The results of the radionuclide method showed disturbed liver function in 51 (46.3%) patients with polycythemia, in 4 patients with myelofibrosis and in 3 with erythrocytosis which were characterized by a decrease in hepatocytic absorptive-excretory function and a decrease in the activity of the reticulo-histiocytic stroma. Liver changes depended on a stage of disease and were detected earlier than with the use of biochemical methods. As distinct from erythrocytes, one-type disorders were noted in the patients with myelofibrosis. Correlation in the lever of RP accumulation in the spleen, its sizes and stage of disease was established. Liver function returned to normal after cytostatic therapy in the patients with stage IIA polycythemia, partially IIB stage, during remission.

[Patho- and morphogenesis of infectious myocarditis]. / Nekotorye voprosy pato- i morfogeneza infektsionnykh miokarditov.

An experimental study in white mice infected with influenza virus A1, staphylococcus, Pseudomonas aeruginosa, Escherichia coli or Proteus, showed toxic vascular, stromal and cardiomyocyte damage in the myocardium within the first 2-3 days (circulation disorders, edema, dystrophic and necrotic changes in cardiomyocytes), which by day 3-5 were replaced by inflammation resulting in the formation of myocarditic cardiosclerosis foci by the 3d-4th week. Certain immune disorders were detected in patients with infectious myocarditis; cardiac antigen was found in the serum of 24%, anticardiac antibodies in 22%, positive blast transformation tests in 7.5%, as well as reduced quantities of T cells. Coons's method at late dates after staphylococcal angina revealed antibodies to myocardial structures in 45.7% of patients, and those to connective tissue in 36.1-31.4%. Myocarditis signs were identified in part of those. A scheme is proposed for the pathogenesis of infectious myocarditis.

[Malignant neoplasms in leukemias]. / Zlokachestvennye novoobrazovaniia pri leikozakh.

The paper presents an evaluation of 1.236 cases of different forms of leukemia. Malignant tumors of different localizations were identified in 21 cases (1.7%). Neoplasms were most frequently associated with chronic lymphoid leukemia (4%), followed by osteomyelosclerosis (1.3%), chronic myeloleukemia (1%), polycythemia (0.9%) and acute leukemia (0.44%). A case of chronic myeloleukemia with concomitant myelosarcoma, thyroid cancer, malignant tumor of kidney and cortical adenoma is presented. The role of immunological disorders and cytostatic therapy in the genesis of "secondary" tumor are discussed.

[Clinical immunological observations of persons in a period of prolonged hypokinesia and the readaptation thereafter]. / Kliniko-immunologicheskie nabliudeniia za liud'mi v period dlitel'noi gipokinezii i readaptatsii posle nee.

In order to study the role of autoimmune processes in the origin of changes occurring during prolonged bed rest, 9 young male test subjects were examined during 30-day and 21--49 day bed rest experiments and recovery periods. No antibodies to antigens of the heart, liver, and kidneys were found. Ten out of 21 test subjects at the end of bed rest and 12 test subjects during recovery showed a high titer of the circulating cardiac antigen. Electro-, mechano, and polycardiographic stadies demonstrated that the subjects with the circulating cardiac antigen displayed more marked changes in the ECG T-wave and the contractile function of the myocardium. These changes were accompanied by activation of the enzymes ALT, ACT and LDH.