[Obstructive sleep apnea: connection with cardiovascular diseases and basic methods of diagnostics].

These literatures are analyses about reasons, pathogenesis, and clinical displays obstructive sleep apnea. Mechanisms over of connection are brought sleep obstructive apnea with development of hypertensive, of cardiac arrhythmias, development of metabolic syndrome, obesity, to pulmonary hypertension, write ventricular insufficiency.

[The effects of hypoxia on initiation and progression of cardiovascular disease in patients with chronic obstructive pulmonary disease].

Hypoxia accompanied chronic obstructive pulmonary disease leads to hypercoagulation, vessels' inflammation, imbalance of oxidative and antioxidative systems. These pathological changes cause arterial hypertension, corpulmonale, metabolism disturbance of the whole organism.

[Impact of arterial stiffness on cardiovascular disease and hypoxia].

We performed an analysis of scientific studies about arterial stiffness impacting on cardiovascular diseases and special mechanisms of its developing. One of these mechanisms is hypoxie endothelial damage. Pulse pressure, aortic pulse wave velocity, the shape of the blood pressure curve, rheography, rheovasography are the methods for determinating arterial stiffness.

[Phospholipids composition of the myocardium in patients with ischemic heart disease and its connection to arrhythmias].

The purpose of this study was to establish phospholipid composition of the myocardium in patients with ischemic heart disease, and to estimate possible correlation of biochemical parameters with myocardium extrasystolic activity. The patients (n = 28) including 15 patients with ischemic heart disease and 13 patients with secondary atrium septum defect (control group) were studied. During surgical intervention the right atrium myocardium bioptates were taken. Phospholipid metabolism was studied in the myocardium samples. At the eve of surgical intervention a holter monitoring was performed. Deep changes in the myocardium lipid metabolism were found, including accumulation of free and estherified cholesterol, lysophospholipids, and sphingomyeline. An increase of free cholesterol content was accompanied by accumulation of sphingomyeline. This can be an evidence of changes in the constitution of lipid rafts. Extrasystoles, particularly ventricular ones, in patients with ischemic heart disease might depend on accumulation of lysophospholipids as they took place simultaneously with it.

[Connection of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease].

The authors presents in the article information on influence of endothelial dysfunction and level of blood leukocytes with clinical course of stable angina pectoris in patients with ischemic heart disease (IHD). 104 male patients aged from 36 to 69 (on average 54.9+/-2.1 years) with IHD and stage I-III stable angina pectoris have been observed. The level of leukocytes, ECG daily monitoring, endotelial function with the help of Celermaera-Sorensena test and plasma concentration of endothelin I have been studied in patients. It was established that there is no significant different (P>0.05) in the level of leukocytes between health persons and patients with IHD independently of functional class of angina pectoris. Patients with IHD had higher level of endothelin I in their blood serum than those in a control group. Patients with IHD have a complicated endothelial-non-dependent vasodilation and an increased thickness of the complex intima-media, there is a negative correlation bond between these characteristics. Patients III functional class of angina pectoris has also reliably decreased endothelial-dependent vasodilation by 37%. Frequency of ventricular extrasystoles in patients with IHD and endothelial dysfunction increases by 12 times.

[State of cellular and humoral immunity in patients with stable angina].

The article presents results of the analysis of indicators immunogenotypic tests of 104 patients with stable stenocardia I-III functional classes. It was established that patients with stable stenocardia have lower level of CD3+ T- lymphocytes, decreased rate of T- lymphocytes helpers/ suppressors (CD4+/CD8+) and increased concentration of circulating immune complexes. These changes did not depend from Functional class of stenocardia and old myocardial infarction. It was established a close interrelation between immunological indicators on the one hand and cholesterol and leukocytosis from another. This correlation has allowed to offer the new classification approach for patients with stenocardia, which considers level of cholesterol and leukocytes.

[Dynamics of immunologic indices in patients with ischemic heart disease on a course of doxazosin therapy]. / Dynamika imunolohichnykh pokaznykiv u khvorykh na ishemichnu khvoroby sertsia pid vplyvom kursovoho likuvannia doksazozynom.

The authors have studied effects of the course treatment with doxasosine, a selective alpha 1-adrenoblocker, on lipid and immunological indices in 46 male subjects with ischemic heart disease presenting with functional class I-III exertional angina. A significant improvement in indices for lipid metabolism has been shown together with absence of negative influence on parameters characterizing immunologic vigour with no worsening of manifestations of T-cellular immune deficiency. In hypercholesterinemia-free middle-aged subjects, posttreatment alterations in the peripheral blood can be regarded as a result of a positive effect on immunological reactivity.

[Endothelial dysfunction in obese hypertensive patients]. / Dysfunktsiia endoteliiu u khvorykh na hipertonichnu khvorobu iz suputnim ozhyrinniam.

A total of 28 patients with stage II hypertensive disease (HD) were examined, their age ranging between 32 to 64 years. Of these, 17 subjects were diagnosed as having had alimentary obesity. The control group comprised 11 subjects with normal level of arterial pressure and body mass. Studied in the above patients were blood serum content of nitrogen oxide by determining levels of its stable metabolites NO2- and NO3- anions. HD patients presenting with normal body weight and those with obesity demonstrated significantly lower blood serum levels of anions NO2- and NO3- as compared to healthy subjects. In HD patients, obesity is accompanied by a more significant reduction in blood serum levels of NO2- and NO3-, which fact might be caused by inhibition of nitratereductase.