[Changes in the lipid peroxidation indices during the sanatorium-health resort treatment of patients with joint diseases, victims in the accident at the Chernobyl Atomic Electric Power Station]. / Izmenenie pokazatelei perekisnogo okisleniia lipidov v protsesse sanitarno-kurortnogo lecheniia u bol'nykh s zabolevaniiami sustavov, postradavshikh pri avarii na Chernobyl'skoi AES.

Joint degeneration and dystrophy observed in some subjects exposed to low-dose radiation after the Chernobyl accident is accompanied with more active production of lipid peroxidation products. This overproduction is corrected by combined sulfurated hydrogen balneotherapy and magnetophoresis of vitamin E on the affected joints.

[Possible approaches to improvement of the efficacy of health resort treatment of women with pelvic inflammatory diseases]. / O vozmozhnykh putiakh povysheniia éffektivnosti kururtnogo lecheniia zhenshchin s vospalitel'nymi zabolevaniiami organov malogo taza.

Hydrogen sulfide balneotherapy paralleled with thymogen (an immunocorrector) therapy improved clinical and immunologic characteristics, ruled out disease recurrences and exacerbations during 12 months after the treatment, and increased the number of pregnancies by 2.5 times in infertile patients.

[Status of immunologic reactivity and prospects of the implementation of occupational selection of workers at a microbiological plant]. / Sostoianie immunologicheskoi reaktivnosti i perspektivy realizatsii professional'nogo otbora rabotnikov mikrobiologicheskogo proizvodstva.

The results of immunologic studies of different groups of workers engaged in the microbiologic synthesis production are presented. The study reveals a very important role of the immune system in the development of various forms of diseases. Differentiated shifts in various chains of cellular and humoral immunity have been identified in practically healthy people and in patients with occupational diseases both in acute condition and at the remittance stage. These shifts are specified by the form and stage of the disease, length of service at the given enterprise and individual immunity characteristics. By means of using immunograms it is possible to select patients with stable, adequate immune type enabling one to go on working at the industrial enterprise without any significant pathologic changes in the body.

[Role of nonspecific factors in the therapeutic action of general hyperthermia in oncologic diseases]. / Rol' nespetsificheskikh faktorov v lechebnom deistvii obshchei gipertermii pri onkologicheskikh zabolevaniiakh.

A study was made of the indices of hemodynamics, the immune status and thiol-disulfide system of the blood of cancer patients subjected to artificial total hyperthermia-hyperglycemia. The authors revealed the phase nature of the body response to total hyperthermia resulting in stimulation of the body adaptation mechanisms with a tendency to the normalization of disturbed homeostatic parameters. The effect of total hyperthermia in cancer therapy depended not only on the factor of selective temperature damage of tumor cells but also on the competence of the system of nonspecific body resistance.

[Effect of levamisole on the immunological reactivity of patients with chronic postoperative osteomyelitis]. / Vliianie levamizola na immunologicheskuiu reaktivnost' bol'nykh khronicheskim posleoperatsionnym osteomielitom.

Clinical observations of 31 patients have shown that levamisole promotes the improvement of immunological indices in patients with chronic postoperative osteomyelitis. In a group of patients treated with levamisole good results were obtained in 84%, while in the group of patients treated without levamisole good results were obtained in 63,9%.

[Effect of whole-body artificial hyperthermia on the immunity function in cancer patients]. / Vliianie iskusstvennoi obshchei gipertermii na sostoianie immuniteta u onkologicheskikh bol'nykh.

The changes in immunologic indexes were studied in 90 cancer patients treated with artificial whole body hyperthermia and hyperglycemia. The changes of the indexes under study showed a double-phase curve after a hyperthermic session--the phase of "heat shock aftermath" involving a short-term decline in certain immunologic indexes was followed by a general improvement of immunologic vigor of cancer patients. Different components of cancer patient immunologic system reacted differently to whole body hyperthermia.

[Macrophagic transformation inhibition phenomenon of peripheral blood mononucleocytes in breast cancer]. / Fenomen ingibirovaniia makrofagal'noi transformatsii mononuklearov perifericheskoi krovi pri rake molochnoi zhelezy.

Macrophagal transformation of mononuclear cells of peripheral blood was evaluated quantitatively in vitro. The study group included 60 patients with breast cancer stages II-IV and 50 healthy subjects. Transformation of mononuclear cells to macrophages in breast cancer patients, particularly, in advanced cases, was found to be reduced, as compared with healthy controls. The serum of cancer patients contains an inhibitor of this process. This was confirmed by mononuclear cell transformation being inhibited both in patients and controls on addition of the serum of cancer patients to both cultures. The function of tumor patients' cells was partially restored, when serum of healthy controls was added. It is suggested to use macrophagal transformation as a test for immunologic examination of tumor patients.

[HL-A system antigen distribution in malignant neoplasm patients]. / Raspredelenie antigenov sistemy HL-A u bol'nykh zlokachestvennykh novoobrazovaniiami.

The distribution of transplantation HL-A antigens in 124 patients (cancer of the stomach, mammary glands, the large intestine, the lung, skeletal sarcoma) was studied in microlymphocyte toxic reaction. A comparison with the results of the analogous examination of healthy persons dwelling in Leningrad indicated certain differences in the frequency of encountering some antigens, and the absence of HLA-B18 antigen among patients. Most frequently (in 62%) an "incomplete set" of antigens was found in a group of patients, antigens typical for the whole locus (more frequently "B") being absent in 7.3%. In 6.4% "extra" (live or more) HL-A antigens were noted. The use of adaptive immunotherapy would significantly change antigenic spectrum of lymphocytes in patients.