[Nonspecific active stimulation of the immune system in the combined treatment of rectal cancer]. / Nespetsificheskaia aktivnaia stimuliatsiia immunnoi sistemy v kompleksnom lechenii raka priamoi kishki.

Results of investigations on the efficacy of splenin as an immunomodulator in the complex treatment of 70 patients with cancer of the rectum revealed its favourable effect on the T- and B-systems of immunity. It was found that immunotherapy effected favourably the immunological properties of the body and this was also supported by clinical data. This makes it possible to recommend splenin as in immunomodulator in the complex treatment of patients with cancer of the rectum.

[Current approach to the treatment of early forms of cervix cancer]. / Sovremennyi podkhod k lecheniiu rannikh form raka sheiki matki.

The effectiveness of treatment of early cancer of the uterine cervix (TIS, Tla and Tlb) is subject to evaluation of tumor stage, concomitant diseases and patient's age as well as the degree of neoplastic process and immunologic vigor. Complex treatment should be unoffensive for immunity. Immunodepressive agents should be used in conjunction with immunostimulants.

[Immunologic disorders and their significance in the treatment of cervical cancer]. / Narusheniia immuniteta i ikh znachenie v lechenii raka sheiki matki.

The study is concerned with immunologic status (cell-mediated and humoral immunity) as a factor influencing the choice of scheme of treatment for carcinoma of cervix uteri. The indexes of immunocompetence should be taken into account in planning the differential treatment of precancer and early forms of carcinoma of cervix uteri. Radiation treatment exerts an immunosuppressive effect. However, immunologic indexes are not affected considerably by laser destruction or surgery. Cryodestruction has a beneficial effect on cell-mediated immunity. Considering these effects as well as the long-term results of different procedures of treatment, laser coagulation, cryogenic destruction or diathermoconization should be recommended for management of carcinoma in situ of cervix uteri, and extensive extirpation of the uterus, unattended by radiation, for Tla.

[Effect of thymosine on oxidative phosphorylation in mitochondria of mouse liver in the dynamics of chemical carcinogenesis]. / Vliianie timozina na okislitel'noe fosforilirovanie v mitokhondriiakh pecheni myshei v dinamike khimicheskogo kantserogeneza.

Oxidative phosphorylation in the mice liver mitochondria with chemical carcinogenesis was studied as affected by thymosine. It is found that under chemical carcinogenesis the energy metabolism (fraction III) lowered and administration of thymosine in the early periods of carcinogenesis favoured an increase in the indices up to the control level. In the late period of carcinogenesis the mentioned effect was not observed. The favourable effect of thymosine on the oxidative phosphorylation was associated with an increase in the immunological indices in the animals under experiment. It is supposed that the activity of thymosine as a hormonal factor includes participation in the energy metabolism regulation.