Statistical analysis of adaptive response in sister chromatid exchanges in human lymphocytes after treatment with very... to control variability

Previous studies have been interpreted as suggesting that low concentrations of N-methyl-N'-nitrosoguanidine (MNNG) have an adaptive effect in the cultured lymphocytes of responsive donors (that is, the cells are protected against the mutagenic effects of a subsequent challenge with a higher concentration of MNNG). The objectives of the present study were to investigate, under stringent experimental conditions, whether a protective effect...(AU)