Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom: a review of the literature.

Paracetamol (acetaminophen) is the most common drug taken in overdose in the UK, accounting for 48% of poisoning admissions to hospital and being involved in an estimated 100-200 deaths per year. In 1998, the UK government introduced legislation that reduced the maximum pack size of all non-effervescent tablets and capsules containing aspirin (acetylsalicylic acid) or paracetamol that can be sold or supplied from outlets other than registered pharmacies from 25 to 16 tablets or capsules. This article reviews the literature to determine the effectiveness of the legislation, focusing specifically on paracetamol poisoning. Seventeen studies on this subject were identified. Three studies found reductions in mortality rates; one study found an increase in mortality rates, while one found an initial reduction followed by an eventual increase; three found no significant difference in mortality rates before and after introduction of the legislation. Five studies found reductions in admissions to liver units, three of these finding a reduction in liver transplantation rates; two further studies found no change in liver function tests and rates of paracetamol-induced acute liver injury or failure. Four studies found a sustained decrease in hospital admissions, while two found an initial decrease followed by an eventual increase. One study found a decline in admissions for paracetamol poisoning and an increase in admissions for non-paracetamol poisoning. Sales data are conflicting, with two studies finding no significant difference in paracetamol sales before and after the introduction of the legislation and one reporting a decline. The severity of overdose appears to have decreased since the maximum permitted packet size was reduced, with five studies reporting a reduction in the number of severe overdoses (measured by numbers of tablets ingested, serum paracetamol concentrations and usage of antidotes). Only two studies reported an increase in the number of severe overdoses.Paracetamol-associated mortality rates, admissions to liver units/liver transplants, hospital admissions and the severity of paracetamol overdose appear to have been decreasing since 1998. However, one study showed that the reductions in mortality and hospital admissions began in 1997; therefore, the contribution of the 1998 legislation to the observed changes is unclear. Most of the studies are based on short-term follow-up so it is difficult to draw any conclusions regarding long-term trends. Many of the studies were also restricted to relatively small areas of the UK; this, combined with a variety of outcome measures, makes it difficult to distinguish any conclusive trends. The studies also suffer from a lack of comparison and control groups. Some studies do not clearly differentiate between the paracetamol preparations covered by the legislation and those not. The limited number of studies to date, combined with a variety of outcome measures, make it difficult to determine with accuracy whether or not the legislation has been a success. More long-term studies are needed to fully assess the impact of the legislation.

A method to estimate the depth of the sciatic nerve during subgluteal block by using thigh diameter as a guide.

BACKGROUND AND OBJECTIVE: The subgluteal approach is common for sciatic nerve block. Although the surface landmarks are clear, the depth of this nerve at this level is difficult to judge. The purpose of this study is to establish a method of estimating the sciatic nerve depth using the anteroposterior (AP) diameter of the thigh as a marker. METHODS: The study was undertaken in 2 phases. Phase 1 entailed review of 100 magnetic resonance images (MRIs) of the pelvis and proximal lower extremity of patients. Measurements were taken of the AP diameter of the thigh at the midpoint of the lesser trochanter and then compared with distances of the sciatic nerves from the skin of the posterior aspect of the thigh at the same level. Phase 2 involved enrolling 40 patients undergoing lower-extremity surgery for whom subgluteal sciatic nerve blocks were indicated. The AP diameters of the thighs were measured from the subgluteal groove to the inguinal groove with the patient in the supine position. Placing the patient in the lateral position, the subgluteal sciatic block was then performed by using a stimulating needle. The distances from the skin at which the sciatic nerves were actually found, as estimated by maximum motor response to stimulus, were noted. RESULTS: Phase 1 showed a mean AP diameter of 18.94 cm +/- 2.61 cm (mean +/- standard deviation [SD]), mean nerve depth of 6.51 cm +/- 1.46 cm (mean +/- SD), and a linear regression slope of 0.48. Phase 2 showed a mean AP diameter of 16.28 cm +/- 2.73 cm (mean +/- SD), a mean nerve depth of 6.99 cm +/- 1.39 cm (mean +/- SD), and a linear regression slope of 0.43. The thigh diameters differed (P < .001) between the groups, but there was no difference in the depth to the sciatic nerve between the 2 groups (P = .07). CONCLUSIONS: Comparing phase 1 and phase 2 datasets shows the slopes of linear regression lines are nearly parallel. The clinical data from phase 2 verify the anatomical data collected in phase 1 and show that the sciatic nerve depth to AP diameter ratio is 0.43 or the depth of the sciatic nerve is approximately 43% of thigh diameter if the patient is positioned in the lateral decubitus position.

At the cords, the pinkie towards: Interpreting infraclavicular motor responses to neurostimulation.

Identification of elicited muscle twitches while performing infraclavicular block of the brachial plexus is often confusing but is critical for success of the block. An easily defined endpoint when evaluating these motor responses to neurostimulation is essential, as it is necessary to block the appropriate cord or cords. In addition to an extensive review of the motor and sensory neuroanatomy of the upper extremity, we describe an easy method to learn and remember the motor response to stimulation of each of the cords of the brachial plexus. If the arm is positioned in the anatomical position, the 5th digit (pinkie) moves laterally (pronation of the forearm) when the lateral cord is stimulated, posteriorly (extension) when the posterior cord is stimulated, and medially (flexion) when the medial cord is stimulated. The pinkie thus moves "toward" the cord that is stimulated.