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1.
Kardiologiia ; 57(10): 20-28, 2017 Oct.
Artigo em Russo | MEDLINE | ID: mdl-29276926

RESUMO

AIM: To study the role of growth factors ((vascular endothelial growth factor (VEGF), platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (FGF-basic)) in the development and progression of chronic heart failure (CHF) in patients with ishcemic heart disease (IHD). MATERIALS AND METHODS: We included in this study 94 patients with CHF. The control group comprised 32 persons. Blood serum levels of growth factors were determined at baseline and after 12 months of observation by enzyme-linked immunosorbent assay. RESULTS: VEGF, PDGF-AB and FGF-basic play an important role in the pathogenesis and progression of heart failure in patients with IHD, determining the increased risk of adverse cardiovascular events in this pathology. Serum activity of growth factors characterizes the severity and course of CHF: with disease progression levels of VEGF and FGF-basic decrease and PDGF-AB concentration increases. Initial low level of VEGF expression regardless of the sex of the patient's sex, significantly low level of FGF-basic and significantly high PDGF-AB in men characterizes unfavorable course of CHF. CONCLUSION: A correlation has been established between blood serum levels of VEGF, PDGF-AB and FGF-basic and severity and course of CHF.


Assuntos
Insuficiência Cardíaca , Humanos , Masculino , Fator de Crescimento Derivado de Plaquetas , Prognóstico , Fator A de Crescimento do Endotélio Vascular
2.
Probl Tuberk ; (3): 44-6, 2000.
Artigo em Russo | MEDLINE | ID: mdl-10900986

RESUMO

The relationship was examined between the bacteriological (growth time, the count of M. tuberculosis colonies) and biochemical (serum haptoglobin and ceruloplasmin levels) indices that characterize the magnitude of inflammation in 653 patients with different forms of pulmonary tuberculosis. Diagnostically, there was a dissimilarity in the biochemical indices studied and there was a stronger relationship between the bacteriological indices and haptoglobin levels.


Assuntos
Ceruloplasmina/metabolismo , Haptoglobinas/metabolismo , Mycobacterium tuberculosis/crescimento & desenvolvimento , Tuberculose Pulmonar/sangue , Tuberculose Pulmonar/microbiologia , Adolescente , Adulto , Idoso , Biomarcadores/sangue , Contagem de Colônia Microbiana , Meios de Cultura , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Índice de Gravidade de Doença
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