Assuntos
Antígenos HLA/genética , Articulação do Ombro , Frequência do Gene , Humanos , Artropatias/genética , FenótipoRESUMO
Twenty patients with heterotopic ossification were HLA typed. The group consisted of 12 patients with severe cranio-cerebral injury and 8 with spinal cord injury. No significant differences in the frequency of any HLA antigens were found in these patients when compared to 631 healthy matched controls. None of the patients was B27 positive.
Assuntos
Lesões Encefálicas/imunologia , Antígenos de Histocompatibilidade/análise , Ossificação Heterotópica/imunologia , Traumatismos da Medula Espinal/imunologia , Adolescente , Adulto , Feminino , Articulação do Quadril/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Ossificação Heterotópica/etiologia , Ossos Pélvicos/imunologia , Espondilite Anquilosante/etiologia , Espondilite Anquilosante/imunologiaRESUMO
Pregnancy sera were found to react differently when screened simultaneously with adenoid and peripheral blood lymphocytes (PBL) obtained from the same individual. Some of the reactions were attributed to the higher sensitivity of adenoid lymphocytes to a low titer HLA or Ia antibody, while others were shown to be due to the expression of DRw (Ia-like) antigens on both T and B lymphocytes separated from adenoids. Positive reactions specific to adenoid lymphocytes, or manifested only following anti-beta2-microglobulin (a-beta2-m) treatment, suggest the presence of antigens other than HLA or Ia on the cell membrane. Unmasking of antigenic sites by the a-beta2-m capping process and rearrangement of the membrane structure may also contribute to the observed phenomena.
Assuntos
Tonsila Faríngea/imunologia , Antígenos de Superfície , Linfócitos B/imunologia , Antígenos HLA , Linfócitos T/imunologia , Animais , Criança , Pré-Escolar , Citotoxicidade Imunológica , Feminino , Teste de Histocompatibilidade , Humanos , Soros Imunes/farmacologia , Gravidez , Perus , Microglobulina beta-2/imunologiaRESUMO
Tissue typing was performed on lymphocytes of 46 Jewish patients with psoriasis vulgaris. HLA B13, B17, B37 and Cw6 were found increased. It is suggested that the increase in the B and C locus antigens is inter-related and may determine the genetic predisposition for the development of this disease.
Assuntos
Antígenos HLA , Psoríase/genética , Epitopos , Antígenos HLA/análise , Humanos , FenótipoRESUMO
One hundred and twenty seven randomly selected Polish Jews were studied for their HLA polymorphism. Gene frequencies exceeding 0.1 were detected for A1, A2, Aw19, B14, Bw16 and Bw17. Significant gametic association was observed for (A1, Bw17), (A2, B27), (Aw26, Bw16), (Aw19, B13) and (A28, B14). Although a predominantly Caucasoid population, the Polish Jews show greater resemblance to Middle Eastern rather than to Northern European Caucasoids.
Assuntos
Antígenos HLA , Judeus , Polimorfismo Genético , Frequência do Gene , Haploidia , Humanos , Israel , Fenótipo , Polônia/etnologiaRESUMO
HLA typing of 123 Israel Jews of Russian origin showed a high frequency for HLA--A1, A2, Aw19 and B14, Bw16 and Bw35 of the A and B loci, respectively. The most frequently occuring haplotypes were (A1, B17), (Aw25, B18), (Aw26, Bw16), (Aw19, B13), (Aw23, B5) and (Aw25, Bw35). This study reveals a striking resemblance in the distribution of frequencies of HLA alleles and haplotypes between Russian Jews and two other East European Jewish communities (presented in this issue) of Polish and Rumanian origin.
Assuntos
Antígenos HLA , Judeus , Polimorfismo Genético , Frequência do Gene , Haploidia , Humanos , Israel , Fenótipo , U.R.S.S./etnologiaRESUMO
One hundred and forty one unrelated Moroccan Jews living in Israel were studied for their HLA polymorphism. Gene frequencies exceeding .1 were found for A1, A2, A3, Aw19, B5, B12, and B13. Significant linkage disequilibrium occurred for (A1, B8), (A2, B5), (A2, Bw21), (A3, Bw40), (A9, B7), (A10, Bw16), (A29, B18) and (Aw19, b14). they represent an intermediate population between Europe and the Middle East.
Assuntos
Antígenos HLA , Judeus , Polimorfismo Genético , Frequência do Gene , Humanos , Israel , Marrocos/etnologia , FenótipoRESUMO
The frequency of histocompatibility antigens (HL-A) was studied in 33 children with celiac disease. HL-A-B8 phenotype was detected in 27.3% of the celiac patients and 7.5% of 395 carefully matched control subjects (X2 for heterogeneity=14.23; P less than 10(-4)). HL-A typing, especially in children, is advocated both as a diagnostic and a prognostic measure. The importance of ethnically matched control subjects is discussed together with a proposal for the construction of such control groups.
Assuntos
Doença Celíaca/imunologia , Antígenos HLA/análise , Antígenos de Histocompatibilidade/análise , Adolescente , Adulto , Doença Celíaca/genética , Criança , Pré-Escolar , Feminino , Seguimentos , Frequência do Gene , Humanos , Lactente , Israel , Masculino , Fenótipo , RiscoRESUMO
The proposed technique provides an inexpensive, totally harmless and rapid procedure for the collection of pregnancy serum having either HLA or anti B-cell cytotoxic activity, Its disadvantages are the necessity for large storage space and the relatively small volume of the obtainable serum.
Assuntos
Coagulação Sanguínea , Teste de Histocompatibilidade/métodos , Soros Imunes/isolamento & purificação , Feminino , Humanos , Período Pós-Parto , GravidezRESUMO
Significantly reduced immunoglobulins were found in 22 patients with phenylketonuria. Tests of cellular immune function which included delayed skin hypersensitivity, T rosettes and PHA transformation were normal. Escherichia coli antibodies and the booster response to tetanus toxoid were also normal.
Assuntos
Formação de Anticorpos , Imunidade Celular , Imunoglobulinas , Fenilcetonúrias/imunologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Hipersensibilidade Tardia , Imunoglobulina A/análise , Imunoglobulina G/análise , Imunoglobulina M/análise , Imunoglobulinas/análise , Lactente , Linfócitos/imunologia , Masculino , Testes CutâneosRESUMO
Six patients suffering from recurrent chest infections were found to lack antibodies to a pooled antigen obtained from six different serotypes of commensal Escherichia coli bacteria. All had normal serum IgG concentrations, but five subsequently benefited from regular gammaglobulin injections. We suggest that the absence of such E. coli antibodies usually indicates a clinically significant defect in antibody production. This simple screening test is of use in the diagnosis of primary and secondary immunodeficiency disorders.
