[Lung eosinophilic syndrome: clinical presentation and cases report]. / Síndrome de eosinofília pulmonar presentación clínica y serie de casos.

INTRODUCTION: Pulmonary eosinophilia syndrome is characterized by a group of diseases that present clinical-radiological conditions, pulmonary eosinophilia or peripheral lung parenchyma in its evolution. We described the clinical and radiological presentation. METHODS: Retrospective descriptive analysis of medical records of 7 patients between 2007 and 2010. RESULTS: The highest numbers of cases were observed in women, with peripheral eosinophilia with values between 550 and 10,000 cells/mm3. The more frequent signs and symptoms were cough, dyspnea, fever and wheezing. The more prevalent radiological findings were alveolar interstitial and alveolar pattern. At CT scan, the most frequent pattern was ground glass. The main diagnoses made were acute and chronic eosinophilic pneumonia in equal proportions, both with response to steroids. CONCLUSIONS: The pulmonary eosinophilia syndrome shares common features with clinical and radiological entities most prevalent, particularly community-adquired pneumonia.

Introducción: El síndrome de eosinofilia pulmonar se caracteriza por un grupo de patologías que presentan afección clínico ­ radiológica pulmonar con eosinofilia periférica o en parénquima pulmonar en su evolución. Materiales y métodos: Se describen las características de presentaciones clínico-radiológicas y evolutivas de pacientes atendidos entre 2007 y 2010 en Hospital Rawson. Resultados: Sobre 8 casos, se observó mayor número de casos en mujeres. Los signos y síntomas principales fueron tos, disnea, fiebre y sibilancias. Los hallazgos radiológicos más prevalentes fueron patrón alveolar y alveolointersticial. En la TAC el más frecuente fue el patrón en vidrio esmerilado. La eosinofilia periférica presentó valores entre 550 y 10.000 cel/mm3. Los pacientes fueron abdordados inicialmente como neumonía adquirida en la comunidad en el 62% de los casos. Los diagnósticos principales realizados fueron neumonía eosinofílica aguda y crónica, ambas con respuesta a esteroides. Conclusiones: El síndrome de eosinofilias pulmonares comparte características clínico-radiológicas comunes con entidades de mayor prevalencia, particularmente NAC.

Cardiopatía isquémica en población inmigrante / Coronary heart disease in immigrant population

Objetivo: Comparar las características de inicio en la cardiopatía isquémica ( CI ) entre la población asignada autóctona e inmigrante. Material y método Estudio descriptivo transversal mediante revisión retrospectiva de historias clínicas informatizadas. Se incluyó a 129 pacientes diagnosticados de CI, de entre 30 y 74 años, autóctonos e inmigrantes, con los factores de riesgo cardiovascular (FRCV) registrados en su historia clínica. Las variables principales fueron la edad en el momento del diagnóstico de la CI, el sexo, el tipo de CI diagnosticada, los FRCV presentes al diagnóstico. También se calculó el riesgo coronario según la escala ReGiCor y se registró el número de arterias coronarias lesionadas de forma significativa en la coronariografía y el tratamiento recibido. Resultados El 40,3% de los pacientes eran inmigrantes y el 73,1% de origen indopaquistaní. La edad media de inicio de CI en autóctonos fue 60,1 años (IC 95%; 58,2-61,9) y en inmigrantes 48,9 años (IC 95%; 46,5-51,3; p < 0,001). Los inmigrantes presentaban cifras menores de colesterol-HDL (p = 0,001), mayores de triglicéridos (p = 0,031) y menor riesgo coronario estimado con la escala ReGiCor (p < 0,001). Entre inmigrantes fue más frecuente la afectación de 3 vasos o tronco común (p = 0,012).Conclusiones Los inmigrantes empezaban con CI una media de 10 años antes que los autóctonos con lesiones coronarias más severas. El riesgo calculado según la función ReGiCor podría estar infraestimado. Conviene conocer estas diferencias para adecuar las estrategias de prevención primaria en la población inmigrante

Objective: To compare the characteristics on debut in coronary artery disease (CAD) between native and immigrant patients. Materials and methods: A cross-sectional retrospective study was performed through the review of computerized medical records. We included 129 patients diagnosed of CAD, from 30 to 74 years, natives and immigrants, with cardiovascular risk factors (CVRF) reported in their medical records. The main variables were age at time of diagnosis of CAD, sex, type of CAD, CVRF present at diagnosis. We also calculated coronary risk using the REGICOR scale and recorded the number of coronary arteries significantly injured on angiography and treatment received. Results: A total of 40.3% of the patients were immigrants, 73.1% of them from South Asia. Mean age at the debut of CAD was 60.1 years in natives (95% CI; 58.2 to 61.9) and 48.9 years in immigrants (95% CI; 46.5 to 51.3, P<.001). The immigrants had lower values of HDLcholesterol (P=.001), higher levels of triglycerides (P=.031) and lower coronary risk estimated on the REGICOR scale (P<.001). Three-vessel or left main coronary artery disease (P=.012) was more frequent among immigrants. Conclusions: Debut of CAD in immigrants appeared 10 years early than in natives with more severe coronary lesions. The risk calculated by REGICOR function could be underestimated in the immigrant group. It is important to know these differences to bring better primary prevention strategies in the immigrant population

Síndrome de eosinofília pulmonar presentación clínica y serie de casos / [Lung eosinophilic syndrome: clinical presentation and cases report].

INTRODUCTION: Pulmonary eosinophilia syndrome is characterized by a group of diseases that present clinical-radiological conditions, pulmonary eosinophilia or peripheral lung parenchyma in its evolution. We described the clinical and radiological presentation. METHODS: Retrospective descriptive analysis of medical records of 7 patients between 2007 and 2010. RESULTS: The highest numbers of cases were observed in women, with peripheral eosinophilia with values between 550 and 10,000 cells/mm3. The more frequent signs and symptoms were cough, dyspnea, fever and wheezing. The more prevalent radiological findings were alveolar interstitial and alveolar pattern. At CT scan, the most frequent pattern was ground glass. The main diagnoses made were acute and chronic eosinophilic pneumonia in equal proportions, both with response to steroids. CONCLUSIONS: The pulmonary eosinophilia syndrome shares common features with clinical and radiological entities most prevalent, particularly community-adquired pneumonia.

Síndrome de eosinofília pulmonar presentación clínica y serie de casos. / [Lung eosinophilic syndrome: clinical presentation and cases report].

INTRODUCTION: Pulmonary eosinophilia syndrome is characterized by a group of diseases that present clinical-radiological conditions, pulmonary eosinophilia or peripheral lung parenchyma in its evolution. We described the clinical and radiological presentation. METHODS: Retrospective descriptive analysis of medical records of 7 patients between 2007 and 2010. RESULTS: The highest numbers of cases were observed in women, with peripheral eosinophilia with values between 550 and 10,000 cells/mm3. The more frequent signs and symptoms were cough, dyspnea, fever and wheezing. The more prevalent radiological findings were alveolar interstitial and alveolar pattern. At CT scan, the most frequent pattern was ground glass. The main diagnoses made were acute and chronic eosinophilic pneumonia in equal proportions, both with response to steroids. CONCLUSIONS: The pulmonary eosinophilia syndrome shares common features with clinical and radiological entities most prevalent, particularly community-adquired pneumonia.

Phylogeny of the large extrachromosomal DNA of organisms in the phylum Apicomplexa.

Organisms in the phylum Apicomplexa appear to have a large extrachromosomal DNA which is unrelated to the mitochondrial DNA. Based on the apparent gene content of the large (35 kb) extrachromosomal DNA of Plasmodium falciparum, it has been suggested that it is a plastid-like DNA, which may be related to the plastid DNA of rhodophytes. However, phylogenetic analyses have been inconclusive. It has been suggested that this is due to the unusually high A+T content of the Plasmodium falciparum large extrachromosomal DNA. To further investigate the evolution of the apicomplexan large extrachromosomal DNA, the DNA sequence of the organellar ribosomal RNA gene from Toxoplasma gondii, was determined. The Toxoplasma gondii rDNA sequence was most similar to the large extrachromosomal rDNA of Plasmodium falciparum, but was much less A+T rich. Phylogenetic analyses were carried out using the LogDet transformation to minimize the impact of nucleotide bias. These studies support the evolutionary relatedness of the Toxoplasma gondii rDNA with the large extrachromosomal rDNA of Plasmodium falciparum and with the organellar rDNA of another parasite in the phylum Apicomplexa, Babesia bovis. These analyses also suggest that the apicomplexan large extrachromosomal DNA may be more closely related to the plastid DNA of euglenoids than those of rhodophytes.