1.
Ann Rheum Dis
; 48(7): 539-41, 1989 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2570550
RESUMO
HLA types, especially HLA-DR3, are associated with the development of toxic reactions in patients with rheumatoid arthritis after treatment with gold or D-penicillamine. In this study, after treatment with sulphasalazine, leucopenia was observed in three patients, who all had a history of leucopenia after previous gold treatment. The HLA types of these patients did not include HLA-DR3; the two patients developing mild leucopenia had HLA-DR2 and the one developing agranulocytosis had HLA-DR4.
Assuntos
Artrite Reumatoide/imunologia , Tiomalato Sódico de Ouro/efeitos adversos , Antígenos HLA-DR/análise , Leucopenia/induzido quimicamente , Sulfassalazina/efeitos adversos , Adulto , Artrite Reumatoide/tratamento farmacológico , Feminino , Humanos , Pessoa de Meia-Idade
2.
Lancet
; 1(8529): 390, 1987 Feb 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2880198