Some deep mycoses diagnosed by histopathology in South Eastern Nigeria.

Twenty-three cases of deep mycoses were histologically diagnosed in 6500 surgical biopsy specimens examined during a three year period (1985-1988) in the Department of Pathology, University of Calabar Teaching Hospital, Calabar, Nigeria. These included 12 cases of African histoplasmosis, four of mycetoma, four of actinomycetoma, two of paranasal aspergilloma, and one of zygomycosis due to Conidiobolus coronatus (rhinoentomophthoromycosis). Involvement of tooth gum and colon in one case each of African histoplasmosis, and of maxillary sinus in two cases of paranasal aspergilloma were unusual clinical manifestations. The need for greater awareness of deep mycoses and for provision of adequate laboratory facilities in Nigeria is emphasized.

Characterization of breast cancer subgroups in an African population.

A detailed prospective study of 58 consecutive breast cancer patients and contemporaneous controls, using age, duration of tumour and presence or absence of poor prognostic signs as clinical parameters, clearly showed that the patients fell into three distinct groups. Group A accounted for 30 per cent of cancers and consisted of young women (21-45 years) with advanced cancers, a short history (3 months or less) and poor prognostic signs; these patients had fast-growing tumours. Group B, to which nearly 60 per cent of patients belonged, was made up of menopausal women (46-50 years) with advanced disease, a history of from 3 months to 1 year and poor prognostic signs; their tumour growth rate was intermediate. Group C made up slightly more than 10 per cent of cases and consisted of postmenopausal women (50 years and above) who gave a long history (1 year or more), and had resectable tumours without poor prognostic signs. Thus, although advanced breast cancer in tropical Africa is due to late presentation in the majority of cases, a small but significant proportion of women have advanced disease in spite of early presentation, attributable to fast tumour growth rate.

Cytologic diagnosis of seminoma metastatic to the central nervous system. A case report.

Seminoma cells detected in the cerebrospinal fluid of a patient who had a seminoma of the testis with widespread metastases are described.