RESUMO
The aim of this study was to investigate the relationship between pulmonary thromboembolism (PTE) and serum endocan levels. The study included 46 patients with a diagnosis of PTE and control group (25 healthy individuals). Serum endocan levels in all participants' blood samples were measured. The average age of the individuals was 61.76â±â16.39 years. There was a significant difference in the serum endocan levels between the patients and those of the control group [321.93âng/l (111.35-2511.33) and 192.77âng/l (118.30-309.02), respectively; Pâ<â0.030]. The serum endocan levels in the submassive [469.41âng/l (258.13-800.54)] and the massive PTE groups [719.18âng/l (319.84-2511.33)] were statistically higher than those in the control group [192.77âng/l (118.30-309.02)] (Pâ<â0.001 and Pâ<â0.001, respectively). In addition, there was a statistically significant difference between the serum endocan levels of the nonmassive PTE group [188.57âng/l (111.35-685.56)] and the submassive PTE group (Pâ<â0.01). The serum endocan levels correlated with the international normalization ratio (INR), right ventricular dilatation (RVD) and SBP (râ=â0.418, Pâ=â0.004; râ=â0.659, Pâ<â0.001; râ=â-0.425, Pâ=â0.003, respectively). In conclusion, serum endocan levels can be considered a practicable biomarker to determine the severity of PTEs and follow-up thrombolytic therapy.