1.
J Invasive Cardiol
; 16(6): A16-21, 2004 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15202451
2.
Arch Virol
; 111(1-2): 15-28, 1990.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2158288
RESUMO
Estramustine phosphate, an estradiol-mustard conjugate, was shown to reversibly inhibit a stage during the first hour of productive adenovirus 2 infection of HeLa cells. This drug, employed in the therapy of advanced prostatic cancer, specifically interacts with microtubule-associated proteins (MAPs) of the cytoskeleton. The results obtained under physiological conditions in vivo suggest a MAPs-interference with the microtubule-mediated vectorial migration of the virus inoculum to the nucleus. Virus attachment, uncoating kinetics and the appearance of established uncoating intermediates were not affected.