1.
Bioorg Med Chem Lett
; 21(22): 6876-9, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21974956
RESUMO
New N-acylhomoserine lactone (AHL) analogues in which the amide function is replaced by a reverse-amide one have been studied as AHL QS modulators. The series of compounds consists of α-(N-alkyl-carboxamide)-γ-butyrolactones, α-(N-alkyl-sulfonamide)-γ-butyrolactones, and 2-(N-alkyl-carboxamide)-cyclopentanones and cyclopentanols. Most active compounds exhibited antagonist activities against LuxR reaching the 30 µM range.