Effect of lynoestrenol and norgestrel on serum lipids in experimental atherosclerosis in rabbits.

PIP: The effect of lynestrenol and norgestrel on serum lipid levels was studied in rabbits with induced hyperlipemia. Lynestrenol and norgestre l were administered orally every day in doses of .33 and 1 mg/kg body weight, respectively. 20 days of treatment with lynestrenol significantly lowered levels of total cholesterol (p less than .02), cholesterol ester (p less than .5), phospholipids (p less than .05), and triglycerides (p less than .05). alpha- and beta-lipoproteins were not significantly changed (p more than .5). Similar effects were observed after cholesterol ether (p less than .5), phospholipids (p less than .02), alpha-lipoproteins (p less than .02), and beta-lipoproteins (p less than .05), though triglycerides were not significatnly changed (p more than .5). Both drugs increased athermatous patches on the aorta. The results demonstrate that lynestrenol and norgestrel both aggravate atherosclerosis in rabbits.^ieng

Urinary estrogens in postmenopausal Egyptian females.

PIP: This study evaluates the effects of age; body weight, and parity of postmenopausal Egyptian females on ovarian function as monitored by urinary estrogen excretion both total and fractionated. It has been established that urinary estrogens are markedly reduced in the postmenopausal than in the childbearing age. 48 postmenopausal Egyptian females with normal liver and adrenocortical functions were studied. Their ages ranged from 1 to 22 years after menopause. 96 urine samples were collected; 50 from 25 females with body weight ranging from 40 to 90 kg, and 46 from 23 females grouped according to parity. The urine samples were used to determine urinary estrogens (total and fractions); 17-oxosteroids and 17-hydroxy corticosteroids. Fasting blood serum samples were also collected for liver function tests. The mean value of 17-oxosteroids was 6.368 + or - 3.1 mg/24 hours urine; mean value of 17-hydroxy corticosteriods was 9.675 + or - 4.2 mg/24 hours urine. All liver function tests were within normal levels. The findings show that urinary estrogens (both total and basic fractions) are inversely proportional to age to 12 years after menopause. Thereafter, urinary estrogens curve to a constant low level up to 22 years after the last menstrual cycle reported. Bodyweight of postmenopausal females did not correlate with urinary estrogen excretion (P 0.1 between different age groups). Nulliparous subjects had lower values of urinary estrone; estradiol 17 B; estriol and total estrogens than multiparous subjects (P 0.005). This was presumed to be due to their ovarian hypofunction^ieng