RESUMO
Mongolian gerbils (Meriones unguiculatus) given a 50% galactose diet developed cataracts similar to those produced in rats maintained on the same diet. This report describes the various stages through which the cataracts progressed. The first sign of a cataract appeared 24 hr after feeding gerbils on the high galactose diet. The pace of cataract maturation was observed to be about twice of that in rats, although the blood galactose levels were similar in the two species. Aldose reductase activity in the gerbil lens was also about twice of that in the rat lens. In conformity with this, dulcitol accumulated to a higher level in gerbil lens during the early phase of cataractogenesis. The data are, therefore, in accordance with the concept that excessive accumulation of polyol in the lens initiates cataract development. The gerbil thus appears to be another suitable model for the study of sugar cataracts.
Assuntos
Catarata/patologia , Gerbillinae , Aldeído Redutase/metabolismo , Animais , Catarata/induzido quimicamente , Catarata/metabolismo , Modelos Animais de Doenças , Galactitol/metabolismo , Galactose , Cristalino/enzimologia , Cristalino/metabolismo , Cristalino/patologia , Ratos , Ratos EndogâmicosAssuntos
Aldeído Redutase/metabolismo , Catarata/induzido quimicamente , Glucose , Cristalino/metabolismo , Desidrogenase do Álcool de Açúcar/metabolismo , Animais , Catarata/metabolismo , Técnicas de Cultura , Gerbillinae , Cristalino/efeitos dos fármacos , Masculino , Malondialdeído/metabolismo , Oxirredução , Ratos , Ratos Endogâmicos , Fatores de Tempo , Vitamina E/farmacologia , XiloseRESUMO
The rabbit eye is hyperopic by approximately 4D. The induction of diabetes leads to a further enhancement in the degree of hyperopia. This enhancement is attenuated substantially by flavonoids as inhibitors of aldose reduction. The development of refractive changes in diabetic lens involves aldose reductase catalyzed polyol synthesis.
