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Mini Rev Med Chem ; 12(7): 671-700, 2012 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22512548

RESUMO

Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the terms antiepileptics /anticonvulsants are used interchangeably, this article reviews their classification according to the chemical structure into: hydantoins, oxazolidinediones, succinimides, barbiturates, amides, benzodiazepines, valproic acid and its derivatives, GABA-analogues, cycloalkanes, semicarbazones, γ butyrolactones (GBLs), imidaquinazolines and pyrrolidine derivatives as well as miscellaneous compounds. In addition, the review discusses the different mechanisms of action of antiepileptic and anticonvulsant agents.


Assuntos
Anticonvulsivantes/química , Anticonvulsivantes/farmacologia , Animais , Anticonvulsivantes/uso terapêutico , Humanos , Convulsões/tratamento farmacológico , Convulsões/metabolismo
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