RESUMO
The novel Coronavirus infection disease is becoming more complex for the humans society by giving death and infected cases throughout the world. Due to this infection, many countries of the world suffers from great economic loss. The researchers around the world are very active to make a plan and policy for its early eradication. The government officials have taken full action for the eradication of this virus using different possible control strategies. It is the first priority of the researchers to develop safe vaccine against this deadly disease to minimize the infection. Different approaches have been made in this regards for its elimination. In this study, we formulate a mathematical epidemic model to analyze the dynamical behavior and transmission patterns of this new pandemic. We consider the environmental viral concentration in the model to better study the disease incidence in a community. Initially, the model is constructed with the derivative of integer-order. The classical epidemic model is then reconstructed with the fractional order operator in the form of Atangana-Baleanu derivative with the nonsingular and nonlocal kernel in order to analyze the dynamics of Coronavirus infection in a better way. A well-known estimation approach is used to estimate model parameters from the COVID-19 cases reported in Saudi Arabia from March 1 till August 20, 2020. After the procedure of parameters estimation, we explore some basic mathematical analysis of the fractional model. The stability results are provided for the disease free case using fractional stability concepts. Further, the uniqueness and existence results will be shown using the Picard-Lendelof approach. Moreover, an efficient numerical scheme has been proposed to obtain the solution of the model numerically. Finally, using the real fitted parameters, we depict many simulation results in order to demonstrate the importance of various model parameters and the memory index on disease dynamics and possible eradication.
RESUMO
This paper presents the analysis of fractional order dynamical system of combined modified function projective synchronization of different systems. Initially, we formulate the model in fractional order and then investigate their associated properties. We then investigate the chaotic behavior of different systems by considering the fractional order parameter. To obtain the simulation results of the models, we use the Runge-Kutta order four scheme and Adams-Bashforth scheme. The obtained results are discussed in detail for the various values of the fractional order parameters. The obtained graphical results reveal the significance of the fractional order modeling.
RESUMO
Gompertz's empirical equation remains the most popular one in describing cancer cell population growth in a wide spectrum of bio-medical situations due to its good fit to data and simplicity. Many efforts were documented in the literature aimed at understanding the mechanisms that may support Gompertz's elegant model equation. One of the most convincing efforts was carried out by Gyllenberg and Webb. They divide the cancer cell population into the proliferative cells and the quiescent cells. In their two dimensional model, the dead cells are assumed to be removed from the tumor instantly. In this paper, we modify their model by keeping track of the dead cells remaining in the tumor. We perform mathematical and computational studies on this three dimensional model and compare the model dynamics to that of the model of Gyllenberg and Webb. Our mathematical findings suggest that if an avascular tumor grows according to our three-compartment model, then as the death rate of quiescent cells decreases to zero, the percentage of proliferative cells also approaches to zero. Moreover, a slow dying quiescent population will increase the size of the tumor. On the other hand, while the tumor size does not depend on the dead cell removal rate, its early and intermediate growth stages are very sensitive to it.
