RESUMO
BACKGROUND: Nothing is reported on Amphilophium paniculatum (L.) Kunth. This study aimed at investigation of chemical constituents of the leaves of Amphilophium paniculatum, grown in Egypt, in addition to pharmacological evaluation. MATERIALS AND METHODS: Isolation of a new compound, along with 5 known flavonoids. Pharmacological activities were carried out on different extracts of A. paniculatum leaves. RESULTS: Identification of a new flavone glycoside, acacetin 8-C-ß-D- glucopyranosy l-(1â2)-α-L-rhamnopyranoside (1) in addition to 5 known flavonoids. The 70% ethanol crud extract and its successive chloroform, ethyl acetate, and 100% ethanol extracts showed significant anti-inflammatoryactivity,analgesic effect, antipyretic activity, antioxidant activity, and anti-hyperglycemic activity. Determination of the median lethal dose (LD50) revealed that the different extracts were safe.
RESUMO
BACKGROUND: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L. METHODS: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-ß-glucopyranoside, myricetin 3-O-â-rhamnopyranoside and gallic acid. RESULTS: Determination of the median lethal dose (LD(50)) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-ß-glucopyranoside, myricetin 3-O-â-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs. CONCLUSION: Administration of extracts of M. communis leaves could be safe at the dose used in this study.
RESUMO
In addition to luteolin and its 7-methyl ether, the CH2Cl2-MeOH (1:1) extract of Cyperus conglomeratus afforded two new prenylflavans identified as 7,3'-dihydroxy-5,5'-dimethoxy-8-prenylflavan and 5,7,3'-trihydroxy-5'-methoxy-8-prenylflavan. The structures were established by CIMS, 1H-NMR, 13C-NMR, H-H COSY, HMQC, HMBC and DEPT analysis.
