Exploring the chondroitin sulfate nanogel's potential in combating nephrotoxicity induced by cisplatin and doxorubicin-An in-vivo study on rats.

In this study, we aim to unveil the potential of itaconyl chondroitin sulfate nanogel (ICSNG) in tackling chronic kidney diseases triggered by the administration of CDDP and doxorubicin (Adriamycin, ADR). To that end, the new drug delivery system (ICSNG) was initially prepared, characterized, and loaded with the target drugs. Thereafter, the in-vivo studies were performed using five equally divided groups of 100 male Sprague-Dawley (SD) rats. Biochemical evaluation and immunohistochemistry studies have revealed the renal toxicity and the ameliorative effects of ICSNG on renal function. When ICSNG-based treatments were contrasted with the CDDP and ADR infected groups, they significantly increased paraoxonase-1 (PON-1), superoxide dismutase (SOD), catalase (CAT) and albumin activity and significantly decreased nitric oxide (NO), tumor necrosis factor alpha (TNF-α), creatinine, urea, and cyclooxygenase-2 (COX-2) activity (p < 0.001). The findings of the current study imply that ICSNG may be able to lessen renal inflammation and damage in chronic kidney disorders brought on by the administration of CDDP and ADR. Interestingly, according to the estimated selectivity indices, the ICSNG-encapsulated drugs have demonstrated superior selectivity for cancer MCF-7 cells, over healthy HSF cells, in comparison to the bare drugs.

Ionic chitosan Schiff bases supported Pd(II) and Ru(II) complexes; production, characterization, and catalytic performance in Suzuki cross-coupling reactions.

Taking the advantage of multifunctional characteristics of chitosan (CS), we have developed new scaffolds (imidazolium-vanillyl-chitosan Schiff bases (IVCSSBs)) for supporting Pd(II) and Ru(II) ions in catalyzing Suzuki coupling reactions. The structures of new materials were described based on their elemental, spectral, thermal, and microscopic analysis. The strong interactions between the binding sites of IVCSSB ligand (OH, H-C=N, and OCH3 groups) and Pd(II) ions resulted in the formation of an excellent heterogeneous catalyst (Pd(II)IVCSSB1) with amazing catalytic activity (up to 99%) and highly stable in the reaction medium. The reusability experiments for Pd(II)IVCSSB1 revealed that there is no appreciable decrease in its catalytic activity even after five consecutive operation runs. Furthermore, this heterogeneous catalyst showed an excellent selectivity toward the cross-coupling reaction where no homo-coupling byproducts were observed in the 1H NMR spectra of the obtained products. Consequently, the present ionic catalytic system may open a new window for a novel generation of ionic bio-based catalysts for organic transformations.