RESUMO
We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group.
Assuntos
Interleucina-1/sangue , Interleucina-6/sangue , Síndrome Nefrótica/metabolismo , Fatores de Necrose Tumoral/sangue , Microglobulina beta-2/urina , Análise de Variância , Nitrogênio da Ureia Sanguínea , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Egito , Feminino , Hemoglobinas/metabolismo , Hospitais Pediátricos , Hospitais Universitários , Humanos , Interleucina-1/imunologia , Interleucina-6/imunologia , Contagem de Leucócitos , Masculino , Síndrome Nefrótica/diagnóstico , Síndrome Nefrótica/tratamento farmacológico , Síndrome Nefrótica/imunologia , Valor Preditivo dos Testes , Recidiva , Indução de Remissão , Albumina Sérica/metabolismo , Resultado do Tratamento , Fatores de Necrose Tumoral/imunologia , Microglobulina beta-2/imunologiaRESUMO
We studied 60 children affected with idiopathic nephrotic syndrome [INS] plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin [IL]-1beta, IL-6, tumour necrosis factor [TNF] and quantitative urinary beta-2-microglobulin [beta-2-m] excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively [100%] the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively [100%] the control group
