Gradient-based generation of intermediate images for heterogeneous tumor segmentation within hybrid PET/MRI scans.

Segmentation of tumors from hybrid PET/MRI scans plays an essential role in accurate diagnosis and treatment planning. However, when treating tumors, several challenges, notably heterogeneity and the problem of leaking into surrounding tissues with similar high uptake, have to be considered. To address these issues, we propose an automated method for accurate delineation of tumors in hybrid PET/MRI scans. The method is mainly based on creating intermediate images. In fact, an automatic detection technique that determines a preliminary Interesting Uptake Region (IUR) is firstly performed. To overcome the leakage problem, a separation technique is adopted to generate the final IUR. Then, smart seeds are provided for the Graph Cut (GC) technique to obtain the tumor map. To create intermediate images that tend to reduce heterogeneity faced on the original images, the tumor map gradient is combined with the gradient image. Lastly, segmentation based on the GCsummax technique is applied to the generated images. The proposed method has been validated on PET phantoms as well as on real-world PET/MRI scans of prostate, liver and pancreatic tumors. Experimental comparison revealed the superiority of the proposed method over state-of-the-art methods. This confirms the crucial role of automatically creating intermediate images in addressing the problem of wrongly estimating arc weights for heterogeneous targets.

Hybrid PET/MRI co-segmentation based on joint fuzzy connectedness and graph cut.

BACKGROUND AND OBJECTIVE: Tumor segmentation from hybrid PET/MRI scans may be highly beneficial in radiotherapy treatment planning. Indeed, it gives for both modalities the suitable information that could make the delineation of tumors more accurate than using each one apart. We aim in this work to propose a co-segmentation method that deals with several challenges, notably the lack of one-to-one correspondence between tumors of the two modalities and the boundaries' smoothing. METHODS: The proposed method is designed to surpass these limits, we propose a segmentation method based on the GCsummax technique. The method takes the advantage of Iterative Relative Fuzzy Connectedness (IRFC) on seeds initialization, and the standard min-cut/max-flow technique for the boundary smoothing. Seed initialization was accurately performed thanks to high uptake regions on PET. Besides, a visibility weighting scheme was adapted to achieve the task of co-segmentation using the IRFC algorithm. Then, given the co-segmented regions, we introduce a morphological-based technique that provides object seeds to standard Graph Cut (GC) allowing it to avoid the shrinking problem. Finally, for each modality, the segmentation task is formulated as an energy minimization problem which is resolved by a min-cut/max-flow technique. RESULTS: The overlap ratio (denoted DSC) between our segmentation results and the ground-truth for PET images is 92.63  ±â€¯ 1.03, while the DSC for MRI images is 90.61  ±â€¯ 3.70. CONCLUSIONS: The proposed method was tested on different types of diseases and it outperformed the state-of-the-art methods. We show its superiority in terms of assymetric relation between PET and MRI and tumors heterogeneity.