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1.
Arch Dis Child Educ Pract Ed ; 109(2): 66-72, 2024 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-36657811

RESUMO

Hirsutism, unwanted terminal hair growth in androgen-dependent areas, is a common presentation to general paediatricians, dermatologists and endocrinologists. Polycystic ovarian syndrome is the most common cause but can be challenging to diagnose in young people due to the significant overlap of features with the healthy adolescent population. There are other rare, but important, causes to consider such as non-classic congenital adrenal hyperplasia and androgen-secreting tumours. Hirsutism carries a significant psychological burden for those living with it. This 15 min consultation piece describes the causes of hirsutism, introduces a novel assessment tool and suggests an approach to investigations and management, including signposting to psychological support.


Assuntos
Neoplasias , Síndrome do Ovário Policístico , Feminino , Adolescente , Humanos , Hirsutismo/diagnóstico , Hirsutismo/etiologia , Hirsutismo/terapia , Androgênios , Síndrome do Ovário Policístico/diagnóstico , Síndrome do Ovário Policístico/terapia , Síndrome do Ovário Policístico/complicações , Neoplasias/complicações , Encaminhamento e Consulta
2.
Arch Dis Child ; 108(11): 871-878, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37045585

RESUMO

Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands. This can be a primary adrenal disorder or secondary to adrenocorticotropic hormone deficiency or suppression from exogenous glucocorticoids. Symptoms of AI in children may initially be non-specific and include growth faltering, lethargy, poor feeding, weight loss, abdominal pain, vomiting and lingering illnesses. AI is treated with replacement doses of hydrocortisone. At times of physiological stress such as illness, trauma or surgery, there is an increased requirement for exogenous glucocorticoids, which if untreated can lead to an adrenal crisis and death. There are no unified guidelines for those <18 years old in the UK, leading to substantial variation in the management of AI. This paper sets out guidance for intercurrent illness, medical, dental and surgical procedures to allow timely and appropriate recognition and treatment of AI and adrenal crisis for children and young people.


Assuntos
Insuficiência Adrenal , Diabetes Mellitus , Criança , Humanos , Adolescente , Consenso , Insuficiência Adrenal/tratamento farmacológico , Insuficiência Adrenal/diagnóstico , Hidrocortisona/uso terapêutico , Glucocorticoides/uso terapêutico , Diabetes Mellitus/tratamento farmacológico
3.
Arch Dis Child Educ Pract Ed ; 107(3): 182-187, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-33832962

RESUMO

Obesity is common among children and young people, with potential for significant clinical consequences. The physical and psychological comorbidities associated with childhood obesity persist into adult life, but many children do not have access to tailored obesity services. We present a framework for the identification, assessment and management of childhood obesity by the non-specialist. We also offer strategies to initiate discussions about weight and to communicate effectively with patients living with obesity.


Assuntos
Obesidade Infantil , Adolescente , Adulto , Criança , Comorbidade , Família , Humanos , Obesidade Infantil/diagnóstico , Obesidade Infantil/epidemiologia , Obesidade Infantil/terapia , Encaminhamento e Consulta
5.
Lancet ; 383(9929): 1665-1676, 2014 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-24412049

RESUMO

Rickets, historically referred to as "the English disease", is common worldwide. Absence of phosphate at the growth plate and mineralising bone surfaces due to inadequate vitamin D supply either from sunlight exposure or diet is the main cause. Inherited disorders causing hypophosphataemia have shown the intricacies of phosphate metabolism. Present advice about the provision of vitamin D to young infants needs to be clarified; the existing guidance is fragmentary and contradictory, and will not help to eradicate the disease.


Assuntos
Hipofosfatemia/complicações , Fosfatos/deficiência , Raquitismo/etiologia , Deficiência de Vitamina D/complicações , Adolescente , Criança , Pré-Escolar , Dieta/efeitos adversos , Humanos , Lactente , Fosfatos/metabolismo , Raquitismo/fisiopatologia , Raquitismo/terapia , Luz Solar , Vitamina D/metabolismo
6.
Arch Dis Child ; 97(10): 870-3, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22789438

RESUMO

BACKGROUND: Supported by meta-analyses, the low-dose Synacthen test (LDST) has gained in popularity, with many believing it to be more sensitive than the supraphysiological standard (250 µg) short ST (SSST), particularly when assessing children prescribed high-dose inhaled corticosteroids (HDICS). However, consensus is lacking about its specific clinical application, what is considered 'low dose' and how that dose is made up. METHODS: To ascertain current use of the short Synacthen test (SST), a questionnaire was emailed to members of the British Society of Paediatric Endocrinology and Diabetes in the UK and Ireland (N=257), requesting a response from each department (N=92). A reminder was sent a month later to members of departments which had not responded. RESULTS: The authors received 39 replies, giving a response rate of 42%. All departments use the SST: 82% use an LDST, 87% use the SSST and 69% use both. The 1 µg dose was used by 44% of hospitals, with the other 56% using seven different doses based on age, weight and body surface area. There were 14 different methods of preparing the low dose test. Additionally, variations in the timings of cortisol sampling and the diagnostic cut-offs for adrenal insufficiency were found. Increased requests for SSTs in children with asthma prescribed HDICS were noted by 44% of respondents, with 67% reporting the detection of adrenal suppression in this group. CONCLUSION: Standardisation of the SST is required to address the considerable variation in the methodology and application of this test in the UK and Ireland.


Assuntos
Insuficiência Adrenal/diagnóstico , Asma/diagnóstico , Cosintropina , Hormônios , Inquéritos e Questionários , Insuficiência Adrenal/tratamento farmacológico , Asma/tratamento farmacológico , Criança , Relação Dose-Resposta a Droga , Humanos , Irlanda , Metanálise como Assunto , Sensibilidade e Especificidade , Reino Unido
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