RESUMO
Rheumatoid arthritis (RA) is a multifactorial disease. A combination of genetic and environmental risk factors contributes to its etiology. Several genes have been reported to be associated with susceptibility to the development of RA. The MHC2TA and FCRL3 genes have been associated previously with RA in Swedish and Japanese populations, respectively. In two recent reports, we show an association between FCRL3 and juvenile rheumatoid arthritis (JRA), and MHC2TA and acute coronary syndrome (ACS) in Mexican population. We assessed the association between three single nucleotide polymorphisms (SNPs) of the MHC2TA (-168G/A; rs3087456, and +16G/C; rs4774) and FCRL3 (-169T/C; rs7528684) genes and rheumatoid arthritis in Mexican population through a genotyping method using allelic discrimination assays with TaqMan probes. Our case-control study included 249 patients with RA and 314 controls. We found no evidence of an association between the MHC2TA -168G/A and +1614G/C or FCRL3 -169T/C polymorphisms and RA in this Mexican population. In this cohort of Mexican patients with RA, we observed no association between the MHC2TA or FCRL3 genes and this autoimmune disease.
Assuntos
Artrite Reumatoide/genética , Proteínas Nucleares/genética , Polimorfismo de Nucleotídeo Único , Receptores Imunológicos/genética , Transativadores/genética , Adulto , Artrite Reumatoide/diagnóstico , Artrite Reumatoide/epidemiologia , Estudos de Casos e Controles , Feminino , Frequência do Gene , Estudos de Associação Genética , Predisposição Genética para Doença , Haplótipos , Humanos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Fenótipo , Fatores de RiscoRESUMO
This retrospective study was undertaken to determine the prevalence and pattern of resistance to antituberculosis drugs among patients with sputum-proven pulmonary tuberculosis who were seen in Taif Chest Hospital over 24 months (between June 1986 and May 1988). The overall prevalence was 22.6% and the majority (53%) were resistant to two drugs. Resistance to streptomycin was most frequent (16%) followed by rifampicin (15%). Resistance to isoniazid was surprisingly low (6.5%). 23.3% of the resistant group had previously received antituberculosis drugs as against 15.4% in the sensitive group. There was a significant association between previous therapy and resistance to antituberculosis drugs. Recommendations to reduce the problem of resistance and to improve compliance are discussed.
