RESUMO
It has been established by method of fluorescentive spectroscopy with using of zond FNA (N-phenilnaftilamine) that under incubation of human erythrocytes in Fenton's system (under intensive generation of oxygen active forms) the hydrophobicity of major hemoglobin fraction is lowered. The changes in the state of hemoglobin A intramolecular structure are correlated with formation of oxidative modification products. It has been shown that aldehydes and ketones of neutral character, which may be oxidative modification products of hydrophobic aminoacid residues, have the highest coefficient of correlation (r =-0.95).
Assuntos
Eritrócitos/citologia , Hemoglobina A/metabolismo , Peróxido de Hidrogênio , Ferro , Estresse Oxidativo , Espécies Reativas de Oxigênio/metabolismo , Técnicas de Cultura de Células , Células Cultivadas , Meios de Cultura Livres de Soro , Eritrócitos/metabolismo , Hemoglobina A/química , Humanos , Interações Hidrofóbicas e Hidrofílicas , Fatores de TempoRESUMO
Metabolic state of erythrocytes is changed under gall-stone disease. The increase of glucose and glycated hemoglobin contents in erythrocytes is combined with intensification of glycolytic reactions and lowered activity of pentose phosphate pathway. These changes may have compensative importance.
Assuntos
Eritrócitos/metabolismo , Cálculos Biliares/sangue , Adulto , Glicólise , Humanos , Pessoa de Meia-Idade , Via de Pentose FosfatoRESUMO
Stomatological examinations of infants aged 6 to 36 months, whose mothers suffer from heart diseases, have revealed that the number of infants with deciduous dental tissue abnormalities grows with the age of the infants, reaching the maximum in those aged 3 years: 63.88 percent. Caries and caries-complicated diseases were recorded in 3-year-old children. This permits regarding the presence of a heart disease in a mother as a risk factor in respect of developing deciduous teeth abnormalities and caries.
Assuntos
Cardiopatias Congênitas/complicações , Cardiopatias/complicações , Dente Decíduo , Adolescente , Adulto , Pré-Escolar , Feminino , Humanos , Lactente , Moscou/epidemiologia , Fatores de Risco , Anormalidades Dentárias/epidemiologia , Anormalidades Dentárias/etiologia , Doenças Dentárias/epidemiologia , Doenças Dentárias/etiologia , População Urbana/estatística & dados numéricosRESUMO
Clinical efficacies of ointments containing alpha- and gamma-interferon and characterized by antiviral activity (2.0 x 10(4) IU) were studied. Antiviral effect of these ointments used in the treatment of 168 children suffering from herpetic stomatitis was assessed from the clinical and immunologic viewpoints. Measurements of secretory IgG carried out over the course of therapy evidenced positive changes in local immunity.
