Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Tipo de estudo
Intervalo de ano de publicação
1.
Eur J Clin Nutr ; 69(11): 1256-61, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26039316

RESUMO

BACKGROUND/OBJECTIVES: Breast cancer is a disease characterised by both oxidative reactions and inflammation. However, few studies have focused on the oxidative and inflammatory biomarkers. The aim of the present study was to evaluate the association between oxidative stress markers and adiposity and clinical staging, as well as the association between the oxidative and the antioxidant biomarkers of women with breast cancer. SUBJECTS/METHODS: A total of 135 cases of breast cancer occurring in 2011 and 2012 were assessed. After exclusions, 101 pre- and post-menopausal women with clinical staging I to IV were eligible to participate in the study. The anthropometric evaluation was performed by collecting data on waist circumference, body mass index and body composition. The socioeconomic and clinical profiles were determined using a standard questionnaire. For the oxidative biomarkers, thiobarbituric acid reactive substances (TBARS), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), low-density lipoprotein(-) (LDL(-)), autoantibody anti-LDL(-) and liposoluble antioxidants (α-tocopherol, retinol and ß-carotene) were analysed. The data were analysed using differences in the mean values, correlation tests and multiple linear regression. RESULTS: The antioxidant levels were higher in postmenopausal women with clinical staging I and II and negative lymph nodes. The TBARS level was associated with clinical staging. Adiposity was associated with levels of retinol and 8-OHdG, whereas LDL(-), 8-OHdG and TBARS were correlated with liposoluble antioxidants after adjusting for the confounders. CONCLUSIONS: The adiposity and clinical staging of patients were associated with oxidative stress. The oxidative and antioxidant biomarkers showed a negative correlation in patients with breast cancer.


Assuntos
Tecido Adiposo/metabolismo , Adiposidade , Antioxidantes/metabolismo , Neoplasias da Mama/metabolismo , Obesidade/metabolismo , Estresse Oxidativo , Adulto , Biomarcadores/sangue , Índice de Massa Corporal , Neoplasias da Mama/sangue , Neoplasias da Mama/complicações , Dano ao DNA , Dieta , Feminino , Humanos , Linfonodos , Estadiamento de Neoplasias , Estado Nutricional , Obesidade/sangue , Obesidade/complicações , Pós-Menopausa , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Vitamina A/sangue , Circunferência da Cintura , alfa-Tocoferol/sangue , beta Caroteno/sangue
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...