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1.
Stat Methods Med Res ; 26(1): 88-107, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24947559

RESUMO

In clinical trials, a surrogate outcome ( S) can be measured before the outcome of interest ( T) and may provide early information regarding the treatment ( Z) effect on T. Many methods of surrogacy validation rely on models for the conditional distribution of T given Z and S. However, S is a post-randomization variable, and unobserved, simultaneous predictors of S and T may exist, resulting in a non-causal interpretation. Frangakis and Rubin developed the concept of principal surrogacy, stratifying on the joint distribution of the surrogate marker under treatment and control to assess the association between the causal effects of treatment on the marker and the causal effects of treatment on the clinical outcome. Working within the principal surrogacy framework, we address the scenario of an ordinal categorical variable as a surrogate for a censored failure time true endpoint. A Gaussian copula model is used to model the joint distribution of the potential outcomes of T, given the potential outcomes of S. Because the proposed model cannot be fully identified from the data, we use a Bayesian estimation approach with prior distributions consistent with reasonable assumptions in the surrogacy assessment setting. The method is applied to data from a colorectal cancer clinical trial, previously analyzed by Burzykowski et al.


Assuntos
Teorema de Bayes , Ensaios Clínicos como Assunto/métodos , Distribuição Normal , Biomarcadores Tumorais , Neoplasias Colorretais/tratamento farmacológico , Progressão da Doença , Humanos , Análise de Sobrevida , Resultado do Tratamento
2.
BJOG ; 121(12): 1564-73, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24735184

RESUMO

OBJECTIVE: Previous studies describing menses duration and heaviness of flow during the menopausal transition (MT) have been short in duration and limited to white women. We estimated the frequency of and risk factors for prolonged bleeding, spotting and heavy bleeding during the MT in an ethnically diverse population. DESIGN: Prospective community-based cohort study. SETTING USA: southeastern Michigan, northern California and Los Angeles, California. POPULATION: A total of 1320 midlife women who participated in the Study of Women's Health Across the Nation (SWAN) Menstrual Calendar Substudy. Participants included African-American, white, Chinese, and Japanese women. METHODS: Women completed daily menstrual calendars from 1996 to 2006, and provided information on hormone therapy, smoking and physical activity. Annual measures included height and weight. Kaplan-Meier survival analysis and multivariable regression were used to analyse the data. MAIN OUTCOME MEASURES: Menses of 10+ days, spotting of 6+ days, heavy bleeding of 3+ days. RESULTS: At least three occurrences of menses 10+ days was reported by 77.7% (95% confidence interval [95% CI] 56.7-93.2), of 6+ days of spotting by 66.8% (95% CI 55.2-78.0) and of 3+ days of heavy bleeding by 34.5% (95% CI 30.2-39.2) of women. Menses of 10+ days, 6+ days of spotting, and 3+ days of heavy bleeding were associated with MT stage, uterine fibroids, hormone use and ethnicity. Body mass index was associated with 3+ days of heavy bleeding. CONCLUSIONS: These data provide clinicians and women with important information about the expected frequency of prolonged and heavy bleeding and spotting during the menopausal transition that may facilitate clinical decision making.


Assuntos
Menopausa/etnologia , Menorragia/etnologia , Menstruação/etnologia , Adulto , Negro ou Afro-Americano , Asiático , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Menopausa/fisiologia , Menstruação/fisiologia , Pessoa de Meia-Idade , Análise Multivariada , Estudos Prospectivos , Autorrelato , Estados Unidos/epidemiologia , População Branca
3.
Inj Prev ; 15(1): 8-12, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19190269

RESUMO

OBJECTIVE: To compare the fatal and non-fatal crash injury risk for children in minivans compared with midsize and large sport utility vehicles (SUVs). DESIGN: Three large population-based sources of US crash data were used--a nationwide cohort of sampled police-reported crashes (NASS-CDS) along with a census of fatal crashes (FARS), plus a large child crash surveillance system, Partners for Child Passenger Safety (PCPS)--collected in 16 states via insurance claim records and validated telephone survey. Each included: 2000-2006 data, occupants aged 0-15 years, traveling in minivan or (midsize/large) SUV, model year 1998-2007. Outcome of interest was parent/driver report of non-fatal injury (Abbreviated Injury Scale scores of 2 or higher) in PCPS and fatal injury in NASS-CDS/FARS. RESULTS: Compared with children riding in SUVs, those in minivans experienced a similar crude reduction in the relative risk of non-fatal injury (PCPS: unadjusted odds ratio (OR) = 0.55) and fatality (NASS-CDS/FARS cohort: unadjusted OR = 0.58). In PCPS, this reduction in injury risk changed little after adjustment for child, driver, and vehicle factors (adjusted OR = 0.56, 95% CI 0.38 to 0.82). Lower fatality risk in the NASS-CDS/FARS cohort was partially explained by the same factors (adjusted OR = 0.76, 95% CI 0.51 to 1.13). CONCLUSIONS: There may be important safety differences in vehicles during a crash that lead to fewer non-fatal injuries to child occupants of minivans compared with SUVs.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Automóveis/estatística & dados numéricos , Ferimentos e Lesões/epidemiologia , Adolescente , Adulto , Idoso , Condução de Veículo/estatística & dados numéricos , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Humanos , Lactente , Equipamentos para Lactente/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Medição de Risco , Fatores de Risco , Cintos de Segurança/estatística & dados numéricos , Estados Unidos/epidemiologia
4.
Inj Prev ; 11(4): 219-24, 2005 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16081750

RESUMO

OBJECTIVES: To describe the trip characteristics of vehicle crashes involving children, and to examine the effect of situational factors on front row seating or inappropriate restraint for young children. METHODS: A cross sectional study was conducted on children <16 years in crashes of insured vehicles in 15 US states, with data collected using insurance claims records and a telephone interview. A descriptive analysis of the characteristics of vehicle crashes involving children was performed. Multivariate Poisson regression was used to identify situational factors associated with inappropriate restraint or front row seating. RESULTS: These data suggest that children were traveling in vehicles involved in crashes that occurred under usual driving circumstances-that is, closer to home (60%), on a local road (56%), during normal daytime hours (71%), within areas with relatively lower posted speed limits (76%). Compared with children involved in morning crashes, those in daytime crashes (RR = 1.65, 95% CI 1.13 to 2.49) or in night-time crashes (RR = 1.63, 95% CI 1.09 to 2.67) were more likely to be sitting in the front seat. Children involved in night-time crashes were more likely to be inappropriately restrained (RR = 1.12, 95% CI 1.01 to 1.22) than those in daytime crashes. Children riding with two or more additional passengers were more likely to be inappropriately restrained (RR = 1.12, 95% CI 1.02 to 1.27) than those with no other passengers. CONCLUSIONS: Educational initiatives should aim to increase the perception that parents have about the potential crash risk of everyday trips. Some situational characteristics of trips were associated with inappropriate restraint and front row seating behaviors for young children.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Cuidado da Criança/normas , Ferimentos e Lesões/prevenção & controle , Adolescente , Automóveis , Criança , Pré-Escolar , Estudos Transversais , Humanos , Lactente , Equipamentos para Lactente/normas , Recém-Nascido , Periodicidade , Fatores de Risco , Segurança , Estados Unidos/epidemiologia , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/etiologia
5.
Inj Prev ; 11(1): 12-7, 2005 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15691982

RESUMO

OBJECTIVES: The first aim was to examine the relationship between driver's age (novice teens, older teens, and adults) and child passenger's restraint status, front row seating, and injury risk. The second aim was to explore whether there was an excess injury risk to child passengers in teen crashes compared to those in adult crashes by examining the contributing factors. METHODS: A cross sectional study involving telephone interviews with insured drivers in a probability sample of 12 163 crashes involving 19 111 children was conducted. Sequential logistic regressions were employed. RESULTS: Among child passengers aged 4-8, appropriate restraint was <1% for novice teens, 4.5% for older teens, and 23.6% for adults. Front row seating for children <13 years was more common in the novice teen group (26.8%) than in the other two groups. Compared with children riding with adults, those with both teen groups experienced excess injury risk. After adjusting for crash severity, there was a 43% reduction in the odds ratio (OR) for novice teens (OR 1.58, 95% confidence interval (CI) 1.14 to 2.19) and a 24% reduction for older teens (OR 2.15, 95% CI 1.42 to 3.26). After adjusting for vehicle type, child's restraint status and front row seating, there was a further 19% reduction in the OR for novice teens (OR 1.37, 95% CI 1.00 to 1.88) and a further 13% reduction for older teens (OR 1.74, 95% CI 1.14 to 2.66). CONCLUSION: These findings suggest ways in which graduated driver licensing laws may be further enhanced to better protect child passengers from the excess injury risk associated with teen crashes.


Assuntos
Acidentes de Trânsito , Condução de Veículo , Ferimentos e Lesões/etiologia , Acidentes de Trânsito/estatística & dados numéricos , Adolescente , Distribuição por Idade , Fatores Etários , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Masculino , Pennsylvania/epidemiologia , Fatores de Risco , Cintos de Segurança , Distribuição por Sexo , Ferimentos e Lesões/epidemiologia , Ferimentos e Lesões/prevenção & controle
6.
J Epidemiol Community Health ; 58(1): 24-30, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14684723

RESUMO

STUDY OBJECTIVES: The Clean Air Act Amendments of 1990 requires that chemical facilities in the US with specified quantities of certain toxic or flammable chemicals file a five year history of accidents. This study considers the relation between the reported accidents and surrounding community characteristics. DESIGN: This study is a retrospective analysis of the association between the demographics of counties in which facilities are located and the risk of accidental chemical release and resulting injuries at those facilities. The "location risk" (the risk that a facility having large volumes of hazardous chemicals is located in a community) and "operations risk" (the risk of an accident itself) are investigated. SETTING: 1994-2000 accident history data from 15 083 US industrial facilities using one or more of 140 flammable or toxic substances above a threshold level. Demographic makeup of 2333 counties surrounding these facilities was determined from the 1990 US census. MAIN RESULTS: Larger and more chemical intensive facilities tend to be located in counties with larger African-American populations and in counties with both higher median incomes and high levels of income inequality. Even after adjusting for location risk there is greater risk of accidents for facilities in heavily African-American counties (OR of accident = 1.9, 95% CI = 1.5 to 2.4). CONCLUSIONS: Further research and policy interventions are required to reduce the probability of locating facilities in an inequitable fashion, as well as health surveillance, and regulatory monitoring and enforcement activities to ensure that hazardous facilities in minority communities prepare and prevent accidental chemical releases to the same standards as elsewhere.


Assuntos
Acidentes/estatística & dados numéricos , Indústria Química/estatística & dados numéricos , Poluição Ambiental/estatística & dados numéricos , Substâncias Perigosas/toxicidade , Classe Social , Negro ou Afro-Americano/estatística & dados numéricos , Humanos , Renda/estatística & dados numéricos , Pobreza/estatística & dados numéricos , Estudos Retrospectivos , Medição de Risco/métodos , Justiça Social , Fatores Socioeconômicos , Estatísticas não Paramétricas , Estados Unidos/epidemiologia , Ferimentos e Lesões/epidemiologia
7.
JAMA ; 286(13): 1593-8, 2001 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-11585482

RESUMO

CONTEXT: Graduated driver licensing (GDL) programs are being adopted in many states to address the high rate of motor vehicle fatalities among teens by requiring teenaged drivers to gain experience and maturity under conditions of relatively low crash risk before gaining full driving privileges. OBJECTIVE: To evaluate the early impact of Michigan's GDL program on traffic crashes among 16-year-old drivers. DESIGN, SETTING, AND SUBJECTS: Analysis of Michigan motor vehicle crash data from 1996 (before GDL program implementation) vs 1998 and 1999 (after GDL program implementation) for 16-year-olds, adjusting for trends among persons 25 years or older. INTERVENTION: Michigan's GDL program, instituted April 1, 1997, for teens younger than 18 years entering the driver license system, includes 3 licensure levels, each with driving restrictions and requirements to progress to the next level. Requirements include extended, supervised practice in the learning level, 2-phase driver education, and night driving restrictions in the intermediate level. MAIN OUTCOME MEASURES: Rates in 1996 vs 1998 and 1999 for all police-reported crashes; for fatal injury, nonfatal injury, and fatal/nonfatal injury combined crashes; for day, evening, and night crashes; for single-vehicle and multivehicle crashes; and for alcohol-related crashes. RESULTS: Overall, the rate of 16-year-old drivers (per 1000 population) involved in crashes declined from 154 in 1996 to 111 in 1999 (relative risk [RR], 0.72; 95% confidence interval [CI], 0.71-0.73). After adjusting for populationwide trends, the overall crash risk for 16-year-olds was significantly reduced in 1999 from 1996 by 25% (adjusted RR, 0.75; 95% CI, 0.74-0.77). There were also significant reductions for nonfatal injury and combined fatal and nonfatal crashes; for day, evening, and night crashes; and for single-vehicle and multivehicle crashes. Fatal crashes declined from 1996 to 1999, but not significantly (RR, 0.74; 95% CI, 0.49-1.14), and alcohol-related crashes continued at a low rate (RR, 1.01; 95% CI, 0.80-1.29). CONCLUSIONS: Analysis of the first 2 full calendar years following Michigan's GDL program implementation indicates substantial crash reductions among 16-year-olds. Future research is necessary to determine if these reductions are maintained and if other jurisdictions achieve similar results.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Exame para Habilitação de Motoristas/estatística & dados numéricos , Adolescente , Condução de Veículo/legislação & jurisprudência , Condução de Veículo/estatística & dados numéricos , Humanos , Michigan/epidemiologia , Risco
8.
Alcohol Clin Exp Res ; 25(3): 403-10, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11290851

RESUMO

BACKGROUND: Alcohol-related injuries, particularly motor vehicle, are an important cause of adolescent mortality. School-based alcohol prevention programs have not been evaluated in terms of driving outcomes. This study examined the effects on subsequent driving of a high school-based alcohol prevention program. METHODS: The Alcohol Misuse Prevention Study included a randomized test of the effectiveness of an alcohol misuse prevention curriculum conducted among 4,635 10th-grade students. Students were assigned to intervention (n = 1,820) or control (n = 2,815) groups and were followed for an average of 7.6 years after licensure, which typically occurred during or shortly after 10th grade. Outcomes examined included alcohol-related and other serious offenses, and at-fault, single-vehicle, and alcohol-related crashes. RESULTS: Only serious offenses (which included alcohol-related) had a significant treatment effect (statistically marginal) after we adjusted for sex, age, race, alcohol use/misuse, family structure, presence of prelicense offenses, age of driver licensure, and parental attitudes toward teen drinking. The effect was found only during the first year of licensure (estimated adjusted relative risk = 0.80, confidence interval = 0.63-1.01). Two first-year serious offense interactions were found. The positive effect was strongest among the largest subgroup of students, those who were drinking less than one drink per week on average before the curriculum, compared with those who drank more than one drink per week (p = 0.009). The effect was also stronger for the small subgroup of students whose parents had not expressed disapproval of teens' drinking, compared with those whose parents had disapproved (p = 0.004). CONCLUSIONS: These findings suggest that a high school-based alcohol prevention program can positively affect subsequent driving, particularly that of students who do not use alcohol regularly. The results highlight the need to start prevention efforts early and extend them beyond the initial exposure to driving. Programs should incorporate the differing backgrounds of the students.


Assuntos
Acidentes de Trânsito/prevenção & controle , Alcoolismo/prevenção & controle , Condução de Veículo/educação , Avaliação de Programas e Projetos de Saúde , Acidentes de Trânsito/estatística & dados numéricos , Adolescente , Alcoolismo/epidemiologia , Condução de Veículo/estatística & dados numéricos , Intervalos de Confiança , Feminino , Seguimentos , Humanos , Masculino , Risco , Estudantes/estatística & dados numéricos
9.
Accid Anal Prev ; 33(1): 117-28, 2001 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11189115

RESUMO

A study of 13,809 young adult drivers in Michigan examined offenses and crashes ('incidents') for an average of 7 years after their original license date. During this period, 73% of subjects committed an offense that resulted in a conviction and 58% had a crash that was reported to the police. Forty-two percent had committed an offense classified as 'serious,' and 21% had an 'at-fault' crash. The odds of an offense being serious decreased approximately 8% per year of licensure, independent of gender or age at licensure. Similarly, the odds of a crash being at-fault decreased overall about 6% per year of licensure, but the decline was more than twice as fast for women as for men. Examining the empirical rates directly, it was found that the rate for minor offenses increased somewhat with time and then stabilized, while the rate for serious offenses declined. Also, offenses were less likely to be serious the later they occurred in the sequence of offenses for an individual. For crashes, the risk of having an at-fault crash declined more rapidly than the risk of a not-at-fault crash, although the rate of decrease began to equalize after approximately 5 years of licensure. The proportion of crashes that were at-fault did not decline over the sequence of crashes for an individual. Although crashes and offenses are positively correlated, they follow different trajectories over the early years of licensure.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Condução de Veículo/legislação & jurisprudência , Licenciamento , Assunção de Riscos , Adolescente , Adulto , Fatores Etários , Feminino , Humanos , Modelos Lineares , Estudos Longitudinais , Masculino , Michigan , Análise de Sobrevida
10.
Artigo em Inglês | MEDLINE | ID: mdl-12214365

RESUMO

The safety of rear-seated child passengers was evaluated across vehicle types. 113,887 children under age 16 in crashes were enrolled as part of an on-going crash surveillance system which links insurance claims data to telephone survey and crash investigation data. Children in the second row suffered less significant injuries than those in the front in all vehicle types except compact extended cab pickup trucks in which the risk for children in the rear was 13% as compared to 2.8% for front-seated occupants. Further research is needed to identify the child and vehicle characteristics which might explain this increased injury risk.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Automóveis , Ferimentos e Lesões/epidemiologia , Escala Resumida de Ferimentos , Adolescente , Criança , Pré-Escolar , Humanos , Incidência , Seguro de Acidentes , Estados Unidos/epidemiologia
11.
Hum Brain Mapp ; 10(3): 107-19, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10912590

RESUMO

Active listening has been reported to elicit a different sensory response from passive listening and is generally observed as an increase in the magnitude of activation. Sensory activation differences may therefore be masked by the effect of attention. The present study measured activation induced by static and modulated tones, while controlling attention by using target-discrimination and passive listening tasks. The factorial design enabled us to determine whether the stimulus-induced activation in auditory cortex was independent of the information-processing demands of the task. Contrasted against a silent baseline, listening to the tones induced widespread activation in the temporal cortex, including Heschl's gyrus (HG), planum temporale, superior temporal gyrus (STG), and superior temporal sulcus. No additional auditory areas were recruited in the response to modulated tones compared to static tones, but there was an increase in the response in the STG, anterior to HG. Relative to passive listening, the active task increased the response in the STG, posterior to HG. The active task also recruited regions in the frontal and parietal cortex and subcortical areas. These findings indicate that preferential responses to the changing spectro-temporal properties of the stimuli and to the target-discrimination task involve distinct, non-overlapping areas of the secondary auditory cortex. Thus, in the present study, differences in sensory activation were not masked by the effects of attention.


Assuntos
Córtex Auditivo/anatomia & histologia , Córtex Auditivo/fisiologia , Percepção Auditiva/fisiologia , Desempenho Psicomotor/fisiologia , Estimulação Acústica , Adolescente , Adulto , Mapeamento Encefálico , Lateralidade Funcional/fisiologia , Humanos , Imageamento por Ressonância Magnética , Testes Neuropsicológicos
12.
Magn Reson Med ; 41(6): 1230-5, 1999 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10371456

RESUMO

The potentially important effect of gradient switching sound on brain function during functional magnetic resonance imaging (fMRI) was studied by comparing experiments with low and high scanner sound levels. To provide a low sound level experiment, a sparse scanning method was used, characterized by long, 9 sec, periods of scanner silence interspersed with 1 sec echoplanar imaging (EPI) bursts. For the condition with high sound levels, extra EPI gradient modules were inserted in the 9 sec inter-image intervals. Visual, motor, or auditory stimuli were presented in the interval between imaging. It was found that with the addition of gradient sounds, auditory activation was significantly decreased while motor and visual activation were not significantly altered. Other general factors relating to fMRI were also examined, such as experimental duration and fatigue. For example, motion of the subjects during the experiments was found to be related to the time spent in the scanner, rather than to the ambient sound level.


Assuntos
Encéfalo/anatomia & histologia , Imageamento por Ressonância Magnética/métodos , Estimulação Acústica , Adulto , Encéfalo/fisiologia , Imagem Ecoplanar/métodos , Feminino , Humanos , Masculino , Atividade Motora , Ruído , Estimulação Luminosa
13.
Hum Brain Mapp ; 7(3): 213-23, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10194620

RESUMO

The use of functional magnetic resonance imaging (fMRI) to explore central auditory function may be compromised by the intense bursts of stray acoustic noise produced by the scanner whenever the magnetic resonance signal is read out. We present results evaluating the use of one method to reduce the effect of the scanner noise: "sparse" temporal sampling. Using this technique, single volumes of brain images are acquired at the end of stimulus and baseline conditions. To optimize detection of the activation, images are taken near to the maxima and minima of the hemodynamic response during the experimental cycle. Thus, the effective auditory stimulus for the activation is not masked by the scanner noise. In experiment 1, the course of the hemodynamic response to auditory stimulation was mapped during continuous task performance. The mean peak of the response was at 10.5 sec after stimulus onset, with little further change until stimulus offset. In experiment 2, sparse imaging was used to acquire activation images. Despite the fewer samples with sparse imaging, this method successfully delimited broadly the same regions of activation as conventional continuous imaging. However, the mean percentage MR signal change within the region of interest was greater using sparse imaging. Auditory experiments that use continuous imaging methods may measure activation that is a result of an interaction between the stimulus and task factors (e.g., attentive effort) induced by the intense background noise. We suggest that sparse imaging is advantageous in auditory experiments as it ensures that the obtained activation depends on the stimulus alone.


Assuntos
Córtex Auditivo/fisiologia , Mapeamento Encefálico/métodos , Imageamento por Ressonância Magnética/métodos , Estimulação Acústica , Adulto , Artefatos , Hemodinâmica/fisiologia , Humanos , Pessoa de Meia-Idade , Valores de Referência , Fatores de Tempo
15.
Can J Nurs Res ; 29(2): 47-67, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9355290

RESUMO

Children who cried excessively at six to eight weeks of age were re-examined at two to four years of age to determine the enduring effects of excessive crying ("colic") on behavioural development, parent-child interaction, and family functioning. The more crying in early infancy, the more family disruptions occurred three years later (r = .29). Analyses showed that early crying had little impact on the children's later behavioural development. No significant major lasting effects on the family related to the infant's early crying behaviour were found. Families with sufficient social and economic resources can be reassured that problems related to early infant crying can be ameliorated over time.


Assuntos
Desenvolvimento Infantil , Choro , Relações Familiares , Psicologia da Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Lactente , Masculino
16.
Ultrasound Med Biol ; 23(3): 437-45, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-9160911

RESUMO

Three-dimensional (3D) reconstructions of arteries can be produced using two-dimensional (2D) intravascular ultrasound (IVUS) images. Any artefact that affects 2D images has the potential to limit the quality of a 3D reconstruction. Using a catheter withdrawal technique, a range of test rigs were used to assess: (i) the effect of rotation of the probe orientation; (ii) the ability to reconstruct the true path of a tortuous vessel; (iii) the effect of image distortion on diameter measurements; (iv) the number of images per unit length used to produce a 3D reconstruction; and (v) the quality of the IVUS 3D reconstruction of a stent. These investigations show that 3D IVUS imaging is prone to artefacts. For 3D IVUS images to be used to quantify the vessel path or to make accurate measurements of vessel dimensions, more information about the catheter tip position and orientation is required than is currently available with the pullback technique.


Assuntos
Ultrassonografia de Intervenção/métodos , Humanos , Modelos Cardiovasculares
17.
Physiol Meas ; 17(4): 259-65, 1996 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-8953624

RESUMO

Detailed images of arteries can be formed by inserting intravascular ultrasound (IVUS) catheters within them. These catheters contain rotating ultrasound transducers and are capable of displaying disease and features such as the layers of artery walls. There is, however, relatively little information available on IVUS resolution even though this is necessary to interpret the images. Techniques for assessing IVUS resolution in three dimensions are described for a 20 MHz Boston Scientific catheter and a Diasonics IVUS scanner as well as the results obtained. Out-of-plane resolution was measured by finding the ultrasound beam thickness. Axial and lateral resolution were assessed by the minimum separation of two point targets when their images could just be distinguished. The out-of-plane resolution was found to improve slightly with distance from the catheter, varying from 2.0-1.5 mm. Lateral resolution worsened in a linear manner with distance. At a distance of 5 mm from the catheter, lateral resolution was 0.83 mm. The axial resolution was the best of the three resolutions and was actually limited by the screen display scale. With the highest magnification the axial resolution was approximately 0.19 mm and was constant with distance.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Ultrassonografia de Intervenção/instrumentação , Artérias/diagnóstico por imagem , Cateterismo , Humanos
18.
Clin Nurs Res ; 5(2): 237-50, 1996 May.
Artigo em Inglês | MEDLINE | ID: mdl-8704668

RESUMO

How families appraise difficult situations contributes to later adaptive functioning. We have observed in both research and practice that when appraising their infants' crying, mothers often compared their own infants' crying to actual or supposed much worse infants. They typically appraised their infants to be crying less than average infants. This phenomenon, defined in the social psychology literature, is called downward comparison. Secondary analysis of an established data set was used to assess the extent of downward comparison and the identification of excessive crying among a sample of 193 primiparous mothers. Mothers appraised their own infants' crying to be less than that of the expected average infant. Mothers who identified their infants as excessive criers made less robust downward comparisons than did mothers who did not identify their infants as excessive criers. Nursing interventions that focus on supporting mothers' positive appraisal and promoting knowledge of infant behaviors, particularly infant crying, are proposed.


Assuntos
Choro , Comportamento do Lactente , Mães/psicologia , Adulto , Cólica/enfermagem , Sinais (Psicologia) , Feminino , Humanos , Lactente , Enteropatias/enfermagem , Masculino , Comportamento Materno , Mães/educação , Paridade , Psicologia Social
20.
Science ; 213(4504): 246-7, 1981 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-17782789
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