1.
Bioorg Med Chem Lett
; 18(2): 793-7, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18053717
RESUMO
A set of regioisomeric 2-substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl fragment at either position 4, 5 or 6 and 2-substituted pyridazin-3(2H)-ones containing the same fragment both at positions 4 and 5 have been synthesized and evaluated as antiplatelet agents. The study allows the identification of a new highly potent platelet aggregation inhibitor (4c).