Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Microb Pathog ; 115: 138-145, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29253598

RESUMO

Lycorine is an alkaloid isolated from bulbs of Pancratium foetidum Pom Amaryllidaceae of the genus Lycoris. It has very strong pharmacodynamics properties and biological effects, among others, antimalarial, antiviral, antitumor, and anti-inflammatory. Lycorine has been identified and characterized by thin layer chromatography, IR and NMR (1H and 13C NMR, COZY, HMBC, HSQC and NOESY). The antibacterial activity of lycorine has been evaluated. Lycorine has a moderate antibacterial activity on the majority of strains studied, nevertheless it is more effective than Streptomycin and Ampicillin against bacteria: P. aeruginosa, En. cloacae. To confirm these results, it is necessary to use qualitative techniques and methods, etc… We performed a virtual docking ligand-lycorine protein screening study to predict and characterize their mode of interaction with the LpxC receptor. Docking results have shown that lycorine can interact with target amino residues studied by hydrogen and metal-ion bonds. In addition, the ADME-Tox profile study has shown that lycorine is all in agreement, either with Lipinski's critics or with the toxicity standards.


Assuntos
Alcaloides de Amaryllidaceae/química , Alcaloides de Amaryllidaceae/farmacologia , Amaryllidaceae/química , Antibacterianos/farmacologia , Simulação de Acoplamento Molecular/métodos , Fenantridinas/química , Fenantridinas/farmacologia , Extratos Vegetais/farmacologia , Alcaloides de Amaryllidaceae/isolamento & purificação , Testes de Sensibilidade Microbiana , Modelos Moleculares , Estrutura Molecular , Marrocos , Fenantridinas/isolamento & purificação , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Relação Estrutura-Atividade
2.
Microb Pathog ; 107: 321-326, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28389346

RESUMO

To investigate biological control methods against post-harvest phytopathogenic fungi in apples, tests on the antifungal activity of essential oil of Melissa officinalis were carried out. The essential oil, obtained by hydrodistillation, was analyzed by gas chromatography coupled with mass spectrometry (GC-MS). Analysis of the essential oil was able to detect 88.7% of the components. The main components are P-mentha-1,2,3-triol (13.1%), P-menth-3-en-8-ol (8.8%), pulegone (8.8%), piperitynone oxide (8.4%) and 2-piperitone oxide (7.3%). The determination of the antifungal activity of the essential oil of M. officinalisis carried out in vitro using the technique of poison food (PF) and the volatile activity test (VA). To carry out these two tests, three phytopathogens that cause the deterioration of apples have been selected: Botrytis cinerea, Penicillium expansum and Rhizopus stolonifer. The overall results of this study suggest that M. officinalis essential oil has potential as a bio-antifungal preservative for the control of post-harvest diseases of apple.


Assuntos
Antifúngicos/química , Antifúngicos/farmacologia , Fungos/efeitos dos fármacos , Malus/microbiologia , Melissa/química , Óleos Voláteis/química , Óleos Voláteis/farmacologia , Agentes de Controle Biológico/química , Agentes de Controle Biológico/farmacologia , Botrytis/efeitos dos fármacos , Botrytis/patogenicidade , Conservantes de Alimentos , Armazenamento de Alimentos , Frutas/microbiologia , Fungos/crescimento & desenvolvimento , Fungos/patogenicidade , Fungicidas Industriais , Cromatografia Gasosa-Espectrometria de Massas/métodos , Testes de Sensibilidade Microbiana , Marrocos , Micélio/efeitos dos fármacos , Micélio/crescimento & desenvolvimento , Penicillium/efeitos dos fármacos , Penicillium/patogenicidade , Doenças das Plantas/microbiologia , Doenças das Plantas/prevenção & controle , Rhizopus/efeitos dos fármacos , Rhizopus/patogenicidade
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...