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6.
Baillieres Clin Obstet Gynaecol ; 12(3): 423-41, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10023430

RESUMO

Childbirth is frequently accompanied by pain. For religious, cultural and philosophical reasons many groups have sought to prevent treatment of pain. Pain may have adverse effects on the mother and fetus. The psychological effects of severe pain should not be overlooked particularly where it is associated with an adverse fetal or maternal outcome. There are a number of different forms of pain relief in labour with differing side-effects and efficacies. The controversy concerning medical management of women in labour has been used to dissuade women from requesting pain relief. This debate has encouraged the use of a patient-centred philosophy of care that encourages the patient to retain control. However, good pain relief may allow the women to retain control if administered in a sensitive manner. The ideal analgesic in labour is discussed. Recent and future developments of analgesia in childbirth are discussed with respect to this.


Assuntos
Complicações do Trabalho de Parto/prevenção & controle , Dor/prevenção & controle , Analgesia por Acupuntura , Analgesia Obstétrica/métodos , Anestesia por Condução/métodos , Comportamento de Escolha , Feminino , Parto Domiciliar , Humanos , Entorpecentes/farmacologia , Entorpecentes/uso terapêutico , Complicações do Trabalho de Parto/fisiopatologia , Dor/fisiopatologia , Educação de Pacientes como Assunto , Gravidez , Terapia de Relaxamento , Apoio Social , Estimulação Elétrica Nervosa Transcutânea
8.
Br J Pharmacol ; 116(4): 2310-4, 1995 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8564265

RESUMO

1. Cholinergic neurones in the basal forebrain are linked to cortical activation and arousal. 2. The present study was designed to examine the hypothesis that clinically relevant doses of halothane (0.1 to 5%) would significantly reduce depolarization-evoked acetylcholine (ACh) release from rat cortical slices. 3. ACh release was measured from rat cortical slices by a chemiluminescent technique. 4. Depolarization-evoked ACh release was inhibited significantly by halothane with an IC50 of 0.38%. This value equates to 0.3 MAC (the minimum alveolar concentration at which no movement occurs to a standard surgical stimulus in 50% of subjects) for the rat. 5. The potent effect of halothane on ACh release suggests that this mechanism may be a target for the action of volatile anaesthetic agents. This in vitro effect on ACh release is consistent with effects of halothane reported in vivo.


Assuntos
Acetilcolina/metabolismo , Córtex Cerebral/metabolismo , Halotano/farmacologia , Potássio/antagonistas & inibidores , Animais , Cálcio/fisiologia , Córtex Cerebral/efeitos dos fármacos , Colina/farmacologia , Feminino , Técnicas In Vitro , Medições Luminescentes , Nootrópicos/farmacologia , Potássio/farmacologia , Ratos , Ratos Wistar
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