[An expert system for differential diagnosis of medullary and oxyphilic cell thyroid carcinoma].

OBJECTIVE: To reveal the quantitative regularities of pathological changes in the nuclei and aggregates of C and B cells and to build an expert system on their basis for the differential diagnosis of medullary and oxyphilic cell thyroid carcinoma. MATERIAL AND METHODS: Puncture smears with histologically verified medullary (C cell) carcinoma and oxyphilic cell (B cell) carcinoma were investigated. The nuclei and aggregates of C cells and B cells (Hürthle cells, oncocytes) were morphometrically examined with a computer color image analyzer on the basis of a light microscope and a digital photo camera. RESULTS: The quantitative regularities of the degree of C and B cell aggregation in medullary and oxyphilic cell thyroid carcinoma were found by morphometry. The threshold values for the aggregates in the comparison groups and their weight coefficients formed the basis for the expert system to differentially diagnose medullary and oxyphilic cell carcinoma at the initial stages of patient examination. The clinical trials showed the high efficiency of the developed expert system.

[The differentiated diagnostic of oxyphilous cellular cancer and oxyphilous cellular adenoma based on the expertise system].

The morphometry was applied to evaluate pathological alterations of degree of aggregation of Hürthle cells under oxyphilous cellular cancer and oxyphilous cellular adenoma of thyroid. The established regularities founded the expertise system on the basis of set of threshold values of 16 qualitative parameters of aggregates and their weighting coefficients. The application of expertise system will allow evaluating with effectiveness of 85.6% the malignant potential of oxyphilous cellular tumor of thyroid of follicular structure at the pre-surgery stage.